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首页> 外文期刊>Journal of orthopaedic research >Silver oxide-containing hydroxyapatite coating has in vivo antibacterial activity in the rat tibia
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Silver oxide-containing hydroxyapatite coating has in vivo antibacterial activity in the rat tibia

机译：含银氧化银的羟基磷灰石涂层在大鼠胫骨中具有体内抗菌活性

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摘要

Bacterial infection is a serious postoperative complication of joint replacement. To prevent infections related to implantation, we have developed a novel antibacterial coating with Ag-containing hydroxyapatite (Ag-HA). In the present study, we examined the antibacterial activity of Ag-HA implant coatings in the medullary cavity of rat tibiae. Forty 10-week-old rats received implantation of Ag-HA- or HA-coated titanium rods, then were inoculated with ～1.0 × 102 colony-forming units of methicillin-resistant Staphylococcus aureus. Bacterial counts were calculated for rats euthanized at 24, 48, and 72 h postoperatively. Serum levels of Ag (in the Ag-HA group only) were calculated for rats euthanized at 24, 48, 72 h and 4 weeks. Radiographic evaluations of bone infection were also performed at 4 weeks. Tibiae from both groups showing infection were evaluated histologically. Significant differences in bacterial counts were seen at 24, 48, and 72 h. Mean concentrations of Ag in serum peaked about 48 h after implantation, then gradually decreased. Mean radiographic scores for infection were significantly lower with Ag-HA implants than with HA implants. Histological examination showed better results for abscesses, bone resorption, and destruction of cortical bone around Ag-HA-coated implants. These results indicate that Ag-HA coatings may help prevent surgical-site infections associated with joint replacement.
机译：细菌感染是关节置换的严重术后并发症。为了防止与植入有关的感染，我们开发了一种具有含有Ag的羟基磷灰石（Ag-Ha）的新型抗菌涂层。在本研究中，我们研究了大鼠胫骨髓腔中Ag-Ha植入涂层的抗菌活性。 40例10周龄大鼠接受了Ag-Ha-或Ha涂覆的钛棒的植入，然后用甲氧西林耐金黄色葡萄球菌的约1.0×102个菌落形成单元接种。针对在术后24,48和72小时安乐死的大鼠计算细菌计数。针对在24,48,72小时和4周内安乐死的大鼠计算血清Ag（仅在Ag-HA组中）。骨感染的射线照相评估也在4周内进行。两组胫骨两组显示出现感染的组织学上。在24,48和72小时内看到细菌计数的显着差异。植入后血清中Ag的平均浓度达到约48小时，然后逐渐降低。与HA植入物的植入物相比，感染的平均射线显微评分显着降低。组织学检查表明，脓肿，骨吸收和皮质骨周围的皮质骨骼的损坏结果表现出更好的结果。这些结果表明，AG-HA涂层可能有助于防止与关节置换相关的外科部位感染。

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