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首页> 外文期刊>Journal of orthopaedic research >Mechanical modulation of growth for the correction of vertebral wedge deformities.
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Mechanical modulation of growth for the correction of vertebral wedge deformities.

机译：椎骨楔形畸形校正生长的机械调节。

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This study tested the following hypotheses: (a) a vertebral wedge deformity created by chronic static asymmetrical loading will be corrected by reversal of the load asymmetry; (b) a vertebral wedge deformity created by chronic static asymmetrical loading will remain if the load is simply removed; and (c) vertebral longitudinal growth rates, altered by chronic static loading, will return to normal after removal of the load. An external fixator was used to impose an angular deformity (Cobb angle of 30 degrees) and an axial compression force (60% body weight) on the ninth caudal (apical) vertebra in two groups of 12 5-week-old Sprague-Dawley rats. This asymmetrical loading was applied to all rats for 4 weeks to create an initial wedge deformity in the apical vertebra. The rats from group I (load reversal) then underwent 1 week of distraction loading followed by 4 weeks of asymmetrical compressive loading with the imposed 30 degree Cobb angle reversed. The rats from group II (load removal) had the apparatus removed and were followed for 5 weeks with no external loading. Weekly radiographs were obtained and serial fluorochrome labels were administered to follow vertebral wedging. After the initial 4-week loading period, the combined average wedge deformity that developed in the apical vertebra of the animals in both groups was 10.7 +/- 4.4 degrees. The group that underwent load reversal showed significant correction of the deformity with the wedging of the apical vertebra decreasing to, on average, 0.1 +/- 1.4 degrees during the 4 weeks of load reversal. Wedging of the apical vertebra in the group that underwent load removal significantly decreased to 7.3 +/- 3.9 degrees during the first week after removal of the load, but no significant changes in wedging occurred after that week. This indicated a return to a normal growth pattern following the removal of the asymmetrically applied loading. The longitudinal growth rate of the apical vertebra also returned to normal following removal of the load. Vertebrae maintained under a load of 60% body weight grew at a rate that was 59.4 +/- 17.0% lower than that of the control vertebrae, whereas after vertebrae were unloaded their growth averaged 102.4 +/- 31.8%. These findings show that a vertebral wedge deformity can be corrected by reversing the load used to create it and that vertebral growth is not permanently affected by applied loading.
机译：该研究测试了以下假设：（a）通过载荷不对称的逆转将校正通过慢性静态不对称负载产生的椎骨楔形畸形; （b）如果慢性静态不对称负载产生的椎骨楔形畸形将留下载荷，如果简单地移除负载; （c）通过慢性静态载荷改变改变的椎体纵向生长率将在去除负荷后恢复正常。外固定器用于施加在12组5周龄Sprague-Dawley大鼠的两组中的第九尾（顶端）椎骨上的角度畸形（Cobb角度）和轴向压缩力（60％体重）和轴向压缩力（60％体重） 。将这种不对称负载施加到所有大鼠4周以在顶端椎骨中产生初始楔形畸形。来自I组（负载反转）的大鼠然后经历了1周的分心加载，然后进行4周的不对称压缩载荷，施加的30度Cobb角逆转。来自II族的大鼠（负载去除）使装置除去，遵循5周，没有外部加载。获得每周射线照相，并施用连续荧光染料标记以遵循椎骨楔形。在初始的4周加载周期之后，两组动物的动物顶端椎骨中开发的组合平均楔形畸形为10.7 +/- 4.4度。接受载荷反转的组显示出在载荷逆转4周内平均下降至平均椎骨的楔形效果的畸形校正。在移除负载后的第一周后，在载荷移除的组中楔入的载荷移除显着降低至7.3 +/- 3.9度，但在该周后没有发生重大楔形变化。这表明在去除不对称施加的载荷后返回到正常生长模式。在去除负荷后，顶点椎骨的纵向生长速率也恢复到正常。维持在60％体重的血管下保持的椎骨比对照椎骨低59.4 +/- 17.0％的速度增长，而在椎骨卸载后，其生长平均为102.4 +/- 31.8％。这些发现表明，通过逆转用于制造它的负荷并且椎体生长未被施加的载荷永久性影响，可以校正椎骨楔形畸形。

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