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首页> 外文期刊>Journal of orthopaedic research >Mechanically modulated cartilage growth may regulate joint surface morphogenesis.
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Mechanically modulated cartilage growth may regulate joint surface morphogenesis.

机译：机械调节的软骨生长可调节关节表面形态发生。

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The development of normal joints depends on mechanical function in utero. Experimental studies have shown that the normal surface topography of diarthrodial joints fails to form in paralyzed embryos. We implemented a mathematical model for joint morphogenesis that explores the hypothesis that the stress distribution created in a functional joint may modulate the growth of the cartilage anlagen and lead to the development of congruent articular surfaces. We simulated the morphogenesis of a human finger joint (proximal interphalangeal joint) between days 55 and 70 of fetal life. A baseline biological growth rate was defined to account for the intrinsic biological influences on the growth of the articulating ends of the anlagen. We assumed this rate to be proportional to the chondrocyte density in the growing tissue. Cyclic hydrostatic stress caused by joint motion was assumed to modulate the baseline biological growth, with compression slowing it and tension accelerating it. Changes in the overall shape of the joint resulted from spatial differences in growth rates throughout the developing chondroepiphyses. When only baseline biological growth was included, the two epiphyses increased in size but retained convex incongruent joint surfaces. The inclusion of mechanobiological-based growth modulation in the chondroepiphyses led to one convex joint surface, which articulated with a locally concave surface. The articular surfaces became more congruent, and the anlagen exhibited an asymmetric sagittal profile similar to that observed in adult phalangeal bones. These results are consistent with the hypothesis that mechanobiological influences associated with normal function play an important role in the regulation of joint morphogenesis.
机译：正常关节的发展取决于子宫的机械功能。实验研究表明，瘫痪胚胎的正常表面形貌未形成瘫痪的胚胎。我们实施了一种用于关节形态发生的数学模型，其探讨了功能关节中产生的应力分布可以调节软骨anlagen的生长并导致一致关节表面的发展。我们模拟了胎儿生命的第55和70天之间的人体手指关节（近端间骨膜关节）的形态发生。基线生物生长率被定义为算上内在生物学影响对胰腺的铰接端的生长。我们认为这种速率与生长组织中的软骨细胞密度成比例。假设由关节运动引起的循环静液压应力调节基线生物生长，压缩速度减慢，张力加速。关节整体形状的变化引起了整个发育中的生长速率的空间差异。当仅包括基线生物生长生长时，两个骨骺尺寸增加但保持凸不一致的关节表面。将基于机械生长的生长调制在软骨中的生长调制引起一个凸形接头表面，其铰接用局部凹面。关节表面变得更加一致，并且anlagen表现出类似于在成人骨骨骨中观察到的不对称矢状型。这些结果与具有与正常功能相关的机械性影响在关节形态发生调节中起重要作用的假设一致。

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