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首页> 外文期刊>Journal of oral rehabilitation >Catabolic changes of rat temporomandibular joint discs induced by unilateral anterior crossbite
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Catabolic changes of rat temporomandibular joint discs induced by unilateral anterior crossbite

机译：单侧前杂交诱导大鼠颞下颌关节盘的分解变化

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摘要

Summary Background The temporomandibular joint (TMJ) disc plays a role in joint movement and in load absorbance and distribution. An experimental unilateral anterior crossbite (UAC) prosthesis induces mandibular condylar cartilage degeneration in rats. However, the changes in the articular disc are still unknown. Objective To describe changes in the TMJ discs of UAC rats. Methods The discs of fifty‐four Sprague‐Dawley rats, equally distributed into a UAC group and an age‐matched sham‐operated control group at 4, 12 and 20?weeks (n?=?9), were evaluated by gross and histomorphological observation and by detection at the mRNA or protein expression levels of the markers related to the matrix elements. Results No macro‐ or micro‐morphological differences were observed between groups. However, there were catabolic degradative changes at the molecular level in the UAC group, showing a significant reduction in the mRNA and/or protein expression levels of many molecules. The reduction became worse with time ( P ??0.05). The reduced molecules included: (a) those related to the extracellular matrix, such as type I collagen, decorin and fibromodulin; (b) those related to chondrogenesis, such as type II collagen and aggrecan; and (c) those related to osteogenesis, such as alkaline phosphatase and runt‐related transcription factor 2. The mRNA expression of vascular endothelial growth factor did not change. In contrast, fibronectin, which can promote wound healing, and its N‐terminal fragment, which can induce cartilage degradation, were accumulated ( P ??0.05). Conclusion TMJ discs were stimulated to catabolic changes by the aberrant dental occlusion and seemed to go to inanimate with time.
机译：摘要背景颞下颌关节（TMJ）光盘在联合运动和负载吸光度和分布中起作用。实验性单侧前杂交体（UAC）假体在大鼠中诱导颌骨髁突软骨变性。然而，关节盘的变化仍然是未知的。目的描述UAC大鼠TMJ椎间盘的变化。方法通过粗略和组织形态学评估五十四个Sprague-Dawley大鼠的圆盘，同等地分布到UAC组和年龄匹配的假手术对照组（n？=Δ9）中，评估通过与基质元素相关的标记的mRNA或蛋白质表达水平的观察和检测。结果在组之间没有观察到宏观或微形态差异。然而，UAC组的分子水平在分子水准下的分解性降解变化，显示出许多分子的mRNA和/或蛋白表达水平的显着降低。随着时间的推移，减少变得更糟（p？＆？0.05）。还原的分子包括：（a）与细胞外基质有关的那些，例如I型胶原蛋白，装饰蛋白和纤维蛋白; （b）与软骨发生有关的那些，例如II型胶原蛋白和聚集蛋白; （c）与骨发生相关的那些，例如碱性磷酸酶和runt相关转录因子2.血管内皮生长因子的mRNA表达没有变化。相反，可以促进伤口愈合的纤连蛋白及其N-末端片段，其可以累积诱导软骨降解（p≤≤0.05）。结论TMJ光盘被异常牙科闭塞的分解变化刺激，似乎随着时间的流逝而变得无生命。

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  • 来源
    《Journal of oral rehabilitation》 |2019年第4期|共9页
  • 作者

    Zhang Hong‐Yun; Xie Mian‐Jiao; Yang Hong‐Xu; Liu Xin; Ren Hao‐Tian; Zhang Mian; Lu Lei; Liu Xiao‐Dong; Zhang Jing; Wang Mei‐Qing;

  • 作者单位

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

    State Key Laboratory of Military Stomatology National Clinical Research Centre for Oral Disease &

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 口腔科学;
  • 关键词

    fibronectins; malocclusion; temporomandibular joint; temporomandibular joint disc; temporomandibular joint disorders;

    机译：纤连蛋白;咬合;颞下颌关节;颞下颌关节盘;颞下颌关节障碍;

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