Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood

Juul-Dam Kristian Lovvik; Ifversen Marianne; Nyvold Charlotte Guldborg; Hansen Maria; Hasle Henrik

首页> 外文期刊>Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology >Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood

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Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood

机译：造血干细胞移植术治疗造血干细胞移植治疗造血干细胞移植治疗外周血血液血液

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Relapse after hematopoietic stem cell transplantation in pediatric acute myeloid leukemia is a fatal event in the majority of cases. Immunotherapy may prevent an impending relapse if instituted at first molecular evidence of disease recurrence. Wilms tumor gene 1 (WT1) is overexpressed in the majority of children and may constitute a useful molecular marker of measurable residual disease applicable for disease monitoring in peripheral blood where the background amplification from healthy hematopoiesis is less prevalent compared with bone marrow. We report the measurable residual disease kinetics from a child with FLT3-internal tandem duplication acute myeloid leukemia where sequential WT1 monitoring in peripheral blood-guided withdrawal of immunosuppression.

机译：在儿科急性髓性白血病中造血干细胞移植后复发是大多数病例的致命事件。免疫疗法可以防止在第一次疾病复发的分子证据中所制定的暂时复发。 Wilms肿瘤基因1（WT1）在大多数儿童中过表达，可能构成可用于疾病监测的可测量残留疾病的有用分子标记，其与骨髓相比，来自健康血液的背景扩增不太普遍。我们报告了来自FLT3 - 内部串联复制急性髓性白血病的儿童可衡量的残留疾病动力学，其中在外周血导向免疫抑制中的顺序WT1监测。

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来源
《Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology》 |2019年第5期|共3页
作者
Juul-Dam Kristian Lovvik; Ifversen Marianne; Nyvold Charlotte Guldborg; Hansen Maria; Hasle Henrik;
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作者单位

Aarhus Univ Hosp Skejby Dept Pediat &

Adolescent Med Aarhus Denmark;

Rigshosp Dept Pediat &

Adolescent Med Copenhagen Univ Hosp Copenhagen Denmark;

Aarhus Univ Hosp Dept Hematol Aarhus Denmark;

Aarhus Univ Hosp Dept Hematol Aarhus Denmark;

Aarhus Univ Hosp Skejby Dept Pediat &

Adolescent Med Aarhus Denmark;

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原文格式 PDF
正文语种 eng
中图分类儿科学;
关键词
acute myeloid leukemia; childhood hematology; hematopoietic stem cell transplantation; measurable residual disease; Wilms tumor gene 1;

机译：急性髓性白血病;儿童血液学;造血干细胞移植;可测量的残余疾病;威尔斯肿瘤基因1;

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1. Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood [J] . Juul-Dam Kristian Lovvik, Ifversen Marianne, Nyvold Charlotte Guldborg, Journal of pediatric hematology/oncology: Official journal of the American Society of Pediatric Hematology/Oncology . 2019,第5期

机译：造血干细胞移植术治疗造血干细胞移植治疗造血干细胞移植治疗外周血血液血液
2. Outcome of allogeneic hematopoietic stem cell transplantation for cytogenetically normal AML and identification of high-risk subgroup using WT1 expression in association with NPM1 and FLT3-ITD mutations [J] . Yoon Jae-Ho, Kim Hee-Je, Jeon Young-Woo, Genes, Chromosomes and Cancer . 2015,第8期

机译：同种异体造血干细胞移植治疗细胞遗传学正常AML的结果以及使用WT1表达结合NPM1和FLT3-ITD突变鉴定高危亚组
3. BAALC and WT1 expressions from diagnosis to hematopoietic stem cell transplantation: Consecutive monitoring in adult patients with core-binding-factor-positive AML [J] . YoonJ.-H., KimH.-J., ShinS.-H., European Journal of Haematology . 2013,第2期

机译：从诊断到造血干细胞移植的BAALC和WT1表达：成年患者核心结合因子阳性AML的连续监测
4. Comparison of cellular immune recovery toward CMV and adenovirus (AdV) between related and unrelated pediatric hematopoietic-stem cell transplantation [C] . Guerin V., Dalle J.-H., Pedron B., European Congress of Immunology . 2009

机译：相关和无关小儿造血 - 干细胞移植与无关的儿科造血 - 干细胞移植细胞免疫恢复对CMV和腺病毒（ADV）的比较
5. The characterization of Epstein-Barr virus infected B cells in the peripheral blood of pediatric solid organ transplant recipients with elevated viral loads. [D] . Schauer, Elizabeth M. 2005

机译：病毒载量升高的小儿实体器官移植受者外周血中爱泼斯坦-巴尔病毒感染的B细胞的特征。
6. Peripheral Blood WT1 Expression Predicts Relapse in AML Patients Undergoing Allogeneic Stem Cell Transplantation [O] . Michele Malagola, Cristina Skert, Giuseppina Ruggeri, -1

机译：外周血WT1表达预测异基因干细胞移植的AML患者复发。
7. Analysis of the Prognostic Effect of Peripheral Blood Lymphocyte and Monocyte Count after Autologous Hematopoietic Stem Cell Transplant in Refractory/Relapsed Hodgkin's Lymphoma in a Pediatric, Adolescent, and Young Adult Population [O] . Jorge Galvez Silva, Ossama M. Maher, Minjeong Park, 2016

机译：在儿科，青少年和年轻成年人群中难治性/复发霍奇金淋巴瘤中自体造血干细胞移植后外周血淋巴细胞和单核细胞计数的预后作用分析

Treatment of Molecular Relapse by Cessation of Immunosuppression After Hematopoietic Stem Cell Transplantation in Pediatric FLT3-ITD AML Monitored by WT1 Expression in Peripheral Blood

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