Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis

Rottboll Lisa Amanda Holm; Friis Christian

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Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis

机译：抗菌剂对肺上皮衬液和肌肉和肌肉的影响，MicrodiaLysis测定的药物物理化学性质

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Introduction: The objectives of this study were to characterize antimicrobial drug penetration into the pulmonary epithelial lining fluid (PELF) and extracellular fluid (ECF) of muscle in relation to physicochemical properties of the drugs (molecular mass, Log D, polar surface area and charge), using intrabronchial microdialysis. The series of drugs tested include gentamicin, sulfadiazine, cefquinome, minocycline and colistin.

机译：介绍：本研究的目的是将抗菌药物渗透到肺上皮衬里液（PELC）和肌肉细胞外液（ECF）相关，与药物的物理化学性质（分子量，LOG D，极面积和电荷），使用Intrabronchial MicrodiaLysis。测试的一系列药物包括庆大霉素，磺胺嗪，头孢喹胺，米诺环素和菌氨酸。

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《Journal of Pharmacological and Toxicological Methods》 |2016年第null期|共8页
作者
Rottboll Lisa Amanda Holm; Friis Christian;
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作者单位

Univ Copenhagen Fac Hlth &

Med Sci Dept Vet Dis Biol Vet Pharmacol &

Toxicol DK-1168 Copenhagen;

Univ Copenhagen Fac Hlth &

Med Sci Dept Vet Dis Biol Vet Pharmacol &

Toxicol DK-1168 Copenhagen;

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原文格式 PDF
正文语种 eng
中图分类药理学;
关键词
Antimicrobials; Colistin; Drug penetration; Extracellular fluid; Gentamicin; Methods; Microdialysis; Pulmonary epithelial lining fluid; Physicochemical characteristics; Pigs;

机译：抗微生物;胚胎;药物渗透;细胞外液;庆大霉素;方法;微透析;肺上皮衬里流体;物理化学特征;猪;

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1. Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis [J] . Rottboll Lisa Amanda Holm, Friis Christian Journal of Pharmacological and Toxicological Methods . 2016,第Null期

机译：通过微透析确定抗菌剂对肺上皮衬里液和肌肉的渗透性以及对药物理化性质的影响
2. Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis [J] . Rottboll Lisa Amanda Holm, Friis Christian Journal of Pharmacological and Toxicological Methods . 2016,第Null期

机译：抗菌剂对肺上皮衬液和肌肉和肌肉的影响，MicrodiaLysis测定的药物物理化学性质
3. Intrabronchial Microdialysis: Effects of Probe Localization on Tissue Trauma and Drug Penetration into the Pulmonary Epithelial Lining Fluid [J] . Rottboll Lisa Amanda Holm, Skovgaard Kerstin, Barington Kristiane, Basic & clinical pharmacology & toxicology. . 2015,第4期

机译：支气管内微透析：探针定位对组织创伤和药物渗透到肺上皮衬里液中的影响
4. Impact of Film Properties and Drug Physicochemical Properties on Diffusion through a Poly(Vinyl Alcohol) Film for the Development of GIRESTM [C] . Caroline Blackshields, Catherine McHugh, Thomas Leonard, Annual meeting exposition of the Controlled Release Society . 2009

机译：膜性质和药物理化性质对通过聚（乙烯醇）膜扩散的影响，以开发GIRESTM
5. The effect of pulmonary edema fluid on ion transport by adult alveolar type II epithelial cells. [D] . Gandhi, Shephali G. 2007

机译：肺水肿液对成年II型肺泡上皮细胞离子迁移的影响。
6. Penetration of GSK1322322 into Epithelial Lining Fluid and Alveolar Macrophages as Determined by Bronchoalveolar Lavage [O] . Odin J. Naderer, Keith A. Rodvold, Lori S. Jones, 2014

机译：支气管肺泡灌洗法测定GSK1322322渗入上皮衬里液和肺泡巨噬细胞
7. Intrabronchial Microdialysis: Effects of Probe Localization on Tissue Trauma and Drug Penetration into the Pulmonary Epithelial Lining Fluid [O] . Rottbøll Lisa Amanda Holm, Skovgaard Kerstin, Barington Kristiane, 2015

机译：支气管内微透析：探针定位对组织创伤和药物渗透进入肺上皮细胞液的影响

Penetration of antimicrobials to pulmonary epithelial lining fluid and muscle and impact of drug physicochemical properties determined by microdialysis

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