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首页> 外文期刊>American journal of clinical pathology. >Abnormal beta-catenin and reduced axin expression are associated with poor differentiation and progression in non-small cell lung cancer.
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Abnormal beta-catenin and reduced axin expression are associated with poor differentiation and progression in non-small cell lung cancer.

机译：非小细胞肺癌中β-catenin异常和毒素表达降低与分化和进展不良有关。

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摘要

We studied the expression of axin and beta-catenin and their relation to clinicopathologic factors in 100 non-small cell lung cancers (NSCLCs) by immunohistochemical analysis. The mutation in exon 3 of the beta-catenin gene was examined by polymerase chain reaction and direct sequencing. Preserved axin expression was significantly higher in well- and moderately differentiated NSCLC samples than in poorly differentiated ones. Reduced membranous expression of beta-catenin was shown in 80 cases, whereas 26 cases had aberrant nuclear expression. Poor differentiation and lymph node metastasis were associated significantly with reduced beta-catenin expression. Lower axin expression was related significantly to higher nuclear beta-catenin expression. However, this study failed to detect any exon 3 mutation in the beta-catenin gene in the 100 NSCLC samples. We conclude that reduced beta-catenin and axin expression might predict poor differentiation in NSCLC. Reduced axin expression, but not mutation in exon 3,might be an important explanation for the abnormal beta-catenin expression in NSCLC.
机译：我们通过免疫组织化学分析了100种非小细胞肺癌（NSCLC）中axin和β-catenin的表达及其与临床病理因素的关系。通过聚合酶链反应和直接测序检查了β-catenin基因第3外显子的突变。高分化和中分化的NSCLC样品中保存的毒素表达明显高于低分化的样品。 β-catenin的膜表达降低，其中80例显示核表达异常。不良的分化和淋巴结转移与降低的β-catenin表达显着相关。较低的毒素表达与较高的核β-连环蛋白表达显着相关。但是，这项研究未能在100个NSCLC样本中检测到β-catenin基因中的第3外显子突变。我们得出的结论是，β-catenin和毒素表达降低可能预示着NSCLC的分化较差。轴突表达降低，但外显子3没有突变，可能是NSCLC中β-catenin表达异常的重要解释。

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