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首页> 外文期刊>Journal of Polymer Research >Development of dopamine biosensor based on polyaniline/carbon quantum dots composite
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Development of dopamine biosensor based on polyaniline/carbon quantum dots composite

机译：基于聚苯胺/碳量子点复合材料的多巴胺生物传感器的研制

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Low level of dopamine (DA) in human brain may lead to neurological diseases, therefore, detection of DA is necessary. This study aims to develop 2 types of DA biosensor, i.e., electrochemical and fluorescent biosensors based on conducting polymer and quantum dot composite. The polyaniline/carbon quantum dots (PANi/CQDs) composite was prepared and characterized by UV-Vis absorption spectroscopy, fluorescence spectroscopy, FT-IR spectroscopy, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). For electrochemical biosensor, the electrospun nanofiber film of PANi/CQDs was fabricated on fluorine doped tin oxide (FTO)-coated glass substrate. Cyclic voltammetry and amperometry were performed to study the electrochemical activity of the PANi/CQDs film toward detection of DA in neutral solution. The obtained film showed good sensitivity for DA sensing with sensitivity of 8.025 nA.cm(-2).mu M(-1)and linear range of 10-90 mu M (R-2 = 0.99) with detection limit of 0.1013 mu M. In addition, for fluorescent biosensor, the fluorescent intensity of PANi/CQDs in PBS solution was quenched with increasing DA concentrations. The PANi/CQDs fluorescent biosensor presented the linear range of 0.1-100 mu M (R-2 = 0.94) with detection limit of 0.0801 mu M. The prepared PANi/CQDs composite can be promising candidate material for future use as DA biosensor in real sample analysis.
机译：人脑中的低水平的多巴胺（DA）可能导致神经疾病，因此，需要检测DA。本研究旨在发展基于导电聚合物和量子点复合材料的2种类型的DA生物传感器，即电化学和荧光生物传感器。制备聚苯胺/碳量子点（PANI / CQDS）复合材料，其特征在于UV-Vis吸收光谱，荧光光谱，FT-IR光谱，扫描电子显微镜（SEM）和X射线光电子谱（XPS）。对于电化学生物传感器，在氟掺杂的氧化锡（FTO）涂覆的玻璃基板上制造PANI / CQDS的电纺纳米纤维膜。进行循环伏安法和安培测定，以研究PANI / CQDS膜对中性溶液中DA检测的电化学活性。所得薄膜对DA感测到8.025na.cm（-2）.mu m（-1）和线性范围的DA感测的良好敏感性，10-90 mu m（r-2 = 0.99），检测限为0.1013 mu m 。另外，对于荧光生物传感器，用增加的DA浓度淬灭PBS溶液中PANI / CQDS的荧光强度。 PANI / CQDS荧光生物传感器的线性范围为0.1-100 mu m（R-2 = 0.94），检测限为0.08010 m米。制备的PANI / CQDS复合材料可以是未来使用作为真实DA生物传感器的候选材料样品分析。

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