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首页> 外文期刊>Journal of liquid chromatography and related technologies >Identification of the factors affecting the retention of weak acid solutes in hybrid micellar systems with cetyltrimethylammonium bromide
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Identification of the factors affecting the retention of weak acid solutes in hybrid micellar systems with cetyltrimethylammonium bromide

机译：鉴定丙基三甲基溴化铵杂交胶束体系中杂交胶束体系保留弱酸溶质的因素的鉴定

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摘要

Retention behavior of ionized and unionized forms of ten weak acid solutes was investigated in hybrid micellar systems with varying cetyltrimethylammonium bromide concentrations (CTAB), acetonitrile (ACN) content and mobile phase pH range from 2.5 to 7.5. It was shown that observed retention patterns are significantly affected by CTAB concentration, ACN volume fraction and analytes' ionization state. The rationale and quantitative description for observed retention behavior was obtained by fitting k values to retention model and calculation of binding constants for both ionized and unionized species. The importance of interaction between analyte anions and positively charged CTAB molecules adsorbed onto stationary phase surface was confirmed. For all solutes, except salicylic acid and furosemide, binding to stationary phase is reduced upon ACN volume fraction increase since the solvent partially desorbs the adsorbed surfactant. Also, the interactions of analytes with micelles are diminished with increase in ACN content because it promotes decrease in micelle aggregation number and its capacity for analyte binding. The additional analysis to identify and interpret molecular descriptors which can best explain the experimental evidence and findings obtained was performed. These findings could provide a new and specific understanding of the interactions between all the components of the hybrid micellar chromatographic system and a good basis for further investigations suggesting the development of generally applicable predictors in structure-retention relationship studies in related chromatographic systems.
机译：在具有不同甲基三甲基溴化铵浓度（CTAB）的杂合胶束体系中，研究了离电离和工会溶质的10种弱酸溶质的保留行为，乙腈（ACN）含量和移动相pH范围为2.5至7.5。结果表明，观察到的保留模式受CTAB浓度，ACN体积分数和分析物电离状态的显着影响。通过拟合K值与保留模型获得的理由和定量描述是通过拟合k值和电离和联合化物种的结合常数的计算获得。确认了分析物阴离子和积极带电的CTAB分子在固定相表面上的相互作用的重要性。对于所有溶质，除了水杨酸和呋塞米外，由于溶剂部分脱离吸附的表面活性剂，因此在ACN体积馏分增加时减少与固定相的结合。而且，通过升高的ACN含量增加，分析物与胶束的相互作用减少，因为它促进了胶束聚集数的降低及其分析物结合的能力。识别和解释能够最佳解释实验证据和发现的分子描述符的额外分析。这些发现可以提供对混合胶束色谱系统所有组分之间的相互作用的新的和具体的理解，以及进一步调查的良好基础，表明在相关色谱系统中的结构保留关系研究中的普遍适用的预测因子的发展。

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