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首页> 外文期刊>Journal of psychosomatic obstetrics and gynaecology >Increased salivary chromogranin A in women with severe negative mood states in the premenstrual phase
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Increased salivary chromogranin A in women with severe negative mood states in the premenstrual phase

机译：在经常阶段增加患有严重阴性情绪状态的妇女唾液色素A.

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The present study investigated whether salivary chromogranin A (CgA), a psychological stress marker associated with sympathetic nervous system activity, changes during the menstrual cycle in women with different degrees of premenstrual psychoemotional symptoms. Forty-five women (28.6±1.3 years) with regular menstrual cycles participated in this study. Salivary CgA and cortisol were measured during the follicular and late-luteal phases. The authors used the Profile of Mood State (POMS) to assess current mood states of subjects in each menstrual phase and divided the subjects into three groups depending on increase of total mood disturbance (TMD), a global measure of affective states of POMS from the follicular to the late-luteal phase: Low (4.1±0.7%), Middle (18.7±1.2%) and High (51.7±7.4%). Results showed no intramenstrual cycle differences in salivary CgA in the Low and Middle groups. Women in the High group, in contrast, had a significantly higher level of salivary CgA in the late-luteal phase compared to that of the follicular phase. Additionally, salivary CgA level significantly and positively correlated with TMD and four emotional subscales: tension-anxiety, depression-dejection, anger-hostility and confusion in the late-luteal phase. No intergroup or menstrual-cycle difference occurred in the salivary cortisol. This study indicates a significant late-luteal increase in salivary CgA, reflecting an increase of sympathetic nerve activity in women who experience a substantial increase (>30%) in a cluster of negative psychoemotional symptoms premenstrually. Furthermore, salivary CgA, as opposed to salivary cortisol, could serve as a reliable noninvasive biomarker to more sensitively evaluate neuropsychophysiological fluctuations during the menstrual cycle.
机译：本研究调查了唾液染色体A（CGA），一种与交感神经系统活动相关的心理应激标志物，在患有不同高度心理学症状的女性中的月经周期内发生变化。在本研究中，常规月经周期的四十五名女性（28.6±1.3岁）。在卵泡和晚期阶段测量唾液CGA和皮质醇。作者使用了情绪状态（POMS）的概况来评估每种月经阶段中受试者的当前情绪状态，并根据总情绪扰动的增加（TMD），这是来自的全球鼠标的全球措施毛囊到后肺阶段：低（4.1±0.7％），中间（18.7±1.2％）和高（51.7±7.4％）。结果表明，低和中组中唾液CGA的血糖循环差异没有。相比之下，高群体中的女性与卵泡相比具有明显更高水平的唾液CGA水平。此外，唾液CGA水平与TMD和四种情绪分产有显着且呈正相关：张力焦虑，抑郁症，愤怒敌对和晚期阶段的混乱。唾液皮质醇中没有发生杂项或月经周期差异。本研究表明唾液CGA的显着晚期肺滞后增加，反映了在先前在一群阴性心理学症状中经历大幅增加（> 30％）的妇女的交感神经活动。此外，与唾液皮质醇相反，唾液CGA可以作为可靠的非侵入性生物标志物，以更敏感地评估月经周期期间的神经核生物学波动。

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