The Rationale for Placebo-Controlled Trials: Methodology and Policy Considerations

Miller FG

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The Rationale for Placebo-Controlled Trials: Methodology and Policy Considerations

机译：安慰剂对照试验的基本原理：方法和政策考虑

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Howick (2009) offers a salutary challenge to arguments regarding the methodological superiority of placebo-controlled trials (PCTs). It would take a detailed commentary to evaluate systematically the merits of his critique. Here I will confine my remarks to three issues: 1) the policy context of trial design aimed at evaluating new treatments for suitability in clinical practice; 2) sample size requirements for PCTs compared with active-controlled trials (ACTs); and 3) the value of small-scale "proof of concept" PCTs in the early phase of efficacy evaluation.

机译：Howick（2009）对安慰剂对照试验（PCTs）的方法学优势提出了质疑。需要系统地评估他的批评的优点的详细评论。在这里，我的发言仅限于三个问题：1）旨在评估新疗法在临床实践中的适用性的试验设计的政策背景; 2）与主动对照试验（ACT）相比，PCT的样本量要求; 3）小规模“概念验证” PCT在功效评估的早期阶段的价值。

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《American journal of bioethics》 |2009年第9期|共2页
作者
Miller FG;
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正文语种 eng
中图分类生物科学;
关键词
Post-Placebo; Paradigm: Ethics; Choice;

机译：安慰剂后;范式：道德;选择;

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The Rationale for Placebo-Controlled Trials: Methodology and Policy Considerations

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