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首页> 外文期刊>Journal of psychiatric research >Lower cerebrospinal fluid CRH concentration in chronic schizophrenia with negative symptoms
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Lower cerebrospinal fluid CRH concentration in chronic schizophrenia with negative symptoms

机译：慢性精神分裂症患者降低脑脊液CRH浓度，阴性症状

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Some patients with schizophrenia have impaired hypothalamic-pituitary-adrenal axis function. However, there is a dearth of studies focusing on corticotropin-releasing hormone (CRH) levels in the brains of schizophrenia patients, which motivated us to examine whether cerebrospinal fluid (CSF) CRH concentrations are altered in these patients. We also examined the possible correlation of CSF CRH level with clinical variables such as schizophrenia symptoms and antipsychotic medication. The study population comprised 20 patients with a diagnosis of schizophrenia according to DSM-5 criteria and 25 healthy controls, who underwent lumbar puncture. Most of the patients were treated with antipsychotic drugs and their doses were converted to chlorpromazine (CP) equivalent values. CSF CRH concentrations were measured by an enzyme immunoassay. Symptom severity was assessed using the Positive and Negative Syndrome Scale (PANSS). There was a significantly lower CSF CRH concentration in the patients than in the controls (Mann-Whitney U test p = 0.014). A significantly negative correlation of CSF CRH levels with PANSS negative scores was found in the patients (Spearman's: rho = -0.58, p = 0.007). However, CSF CRH concentrations were not significantly correlated with the PANSS total (rho = - 0.035, p = 0.89), positive (rho = 0.25, p = 0.30), or general psychopathology (rho = 0.13, p = 0.59) scores. No significant correlation was found with CP equivalent values (rho = 0.00, p = 1.00). In conclusion, we found that the patients with schizophrenia had lower CSF CRH concentrations compared to the controls and that the lower CSF CRH was associated with negative symptoms of the illness. Further studies in a larger sample and in drug-free patients are warranted.
机译：一些患有精神分裂症的患者患有下丘脑 - 垂体 - 肾上腺轴功能受损。然而，有一种研究的研究，重点是精神分裂症患者大脑中的皮质培素释放激素（CRH）水平，这激发了美国脑脊液（CSF）CRH浓度是否在这些患者中改变。我们还研究了CSF CRH水平与临床变量的可能相关性，例如精神分裂症症状和抗精神病药。根据DSM-5标准和25名健康对照组，研究人群患者诊断为诊断性精神分裂症和25名健康对照，他们接受了腰椎穿刺。大多数患者用抗精神病药物处理，它们的剂量转化为氯丙嗪（CP）当量值。通过酶免疫测定法测量CSF CRH浓度。使用正综合征尺度（平移）评估症状严重程度。患者中显着降低了CSF CRH浓度而不是对照（Mann-Whitney U测试P = 0.014）。在患者中发现了CSF CRH水平与平底锅负数的显着负相关性（Spearman：Rho = -0.58，P = 0.007）。然而，CSF CRH浓度与总共平移没有显着相关（RHO = - 0.035，P = 0.89），阳性（rhO = 0.25，p = 0.30），或一般精神病理学（RHO = 0.13，P = 0.59）得分。 CP等值值没有发现显着的相关性（RHO = 0.00，P = 1.00）。总之，我们发现，与对照相比，精神分裂症患者具有较低的CSF CRH浓度，并且下部CSF CRH与疾病的阴性症状有关。有必要进一步研究较大的样品和无毒患者。

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