• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of psychoactive drugs >Long-Term Heavy Recreational Cannabis Use and Serum Delta-9-Tetrahydrocannabinol Levels are not Associated with an Impaired Liver Function in Cannabis Dependents
【24h】

Long-Term Heavy Recreational Cannabis Use and Serum Delta-9-Tetrahydrocannabinol Levels are not Associated with an Impaired Liver Function in Cannabis Dependents

机译：长期重型休闲大麻使用和血清Delta-9-四氢吲哚甘油醇水平与大麻家族的肝功能受损

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

To shed more light on the influence of chronic cannabis use on liver function, we performed a post-hoc analysis of routine lab data of 42 inpatient treatment-seeking (9 female, median: 27 years old) pure cannabis dependents. Serum liver function tests (LFT: transaminases, bilirubin), C-reactive protein (CRP), carbohydrate-deficient transferrin (CDT), and body mass index (BMI) were considered. The LFT were correlated with CDT, BMI, and cannabis-related clinical data (CR); i.e., the serum levels of delta-9-tetrahydrocannabinol (THC) and its major metabolites 11-hydroxy-delta-9-tetrahydrocannabinol (THC-OH) and 11-nor-delta-9-tetrahydrocannabinol-9-carboxylic acid (THC-COOH), plus the cannabis-history data. The LFT was normal in 32 (76.2%) patients. There was no significant association of LFT with BMI, CRP, CDT, and CR. No significant differences were found between the group with elevated LFT (N = 10) and the group without elevated LFT (N = 32) regarding BMI, CRP, CDT, and CR, except for THC-OH, which was even lower in the elevated-LFT group. These results argue against a relevant harmful impact of chronic cannabis inhalation on the liver function of relatively healthy humans (apart from nicotine dependence). Specifically, the liver function tests were not significantly influenced by THC and THC-COOH levels, both objective markers for the amount and duration of prior cannabis use.
机译：为了缩小慢性大麻使用对肝功能的影响，我们进行了42位住院治疗的常规实验室数据后的HOC分析（9名女性，中位数：27岁）纯粹的大麻依赖。考虑血清肝功能试验（LFT：转氨酶，胆红素），C-反应蛋白（CRP），碳水化合物缺陷型转移素（CDT）和体重指数（BMI）。 LFT与CDT，BMI和Cancabis相关的临床数据（CR）相关;即，血清δ-9-四氢萘酚（THC）及其主要代谢物11-羟基 - δ-9-四氢尼酚（THC-OH）和11-δ-9-四氢尼酚-9-羧酸（THC- COOH），加上大麻历史数据。 LFT在32例（76.2％）患者中正常。 LFT与BMI，CRP，CDT和CR没有显着关联。在具有升高的LFT（n = 10）和没有关于BMI，CRP，CDT和CR的基团之间没有发现显着的差异，除了THC-OH之外，在升高的情况下甚至降低-lft组。这些结果反对慢性大麻吸入对相对健康人类肝功能（除尼古丁依赖）的相关有害影响。具体地，肝功能试验没有受到THC和THC-COOH水平的显着影响，目的标志物用于现有大麻使用的量和持续时间。

著录项

  • 来源
    《Journal of psychoactive drugs》 |2018年第4期|共6页
  • 作者

    Bonnet Udo; Canbay Ali; Specka Michael; Scherbaum Norbert;

  • 作者单位

    Univ Duisburg Essen Acad Teaching Hosp Evangel Krankenhaus Castrop Rauxel Dept Psychiat;

    Otto Von Guericke Univ Dept Gastroenterol Hepatol &

    Infect Dis Magdeburg Germany;

    Univ Duisburg Essen LVR Hosp Essen Fac Med Dept Psychiat &

    Psychotherapy Essen Germany;

    Univ Duisburg Essen LVR Hosp Essen Fac Med Dept Psychiat &

    Psychotherapy Essen Germany;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 药学;
  • 关键词

    Cannabis abuse; liver function; THC;

    机译：大麻滥用;肝功能;THC;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号