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首页> 外文期刊>Journal of Reproductive Immunology >Cytotoxic potential of decidual NK cells and CD8+T cells awakened by infections
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Cytotoxic potential of decidual NK cells and CD8+T cells awakened by infections

机译：蜕膜NK细胞的细胞毒性潜力和CD8 + T细胞被感染唤醒

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To establish a healthy pregnancy the maternal immune system must tolerate fetal allo-antigens, yet remain competent to respond to infections. The ability of decidual NK cells (dNK) to promote migration of fetal extravillous trophoblasts (EVT) and placental growth as well as the capacity of EVT to promote immune tolerance are topics of high interest and extensive research. However, the problem of how dNK and decidual CD8+ T cells (CD8+ dT) provide immunity to infections of the placenta and the mechanisms that regulate their cytolytic function has thus far largely been ignored. Fetal EVT are the most invasive cells of the placenta and directly interact with maternal decidual immune cells at this maternal-fetal interface. Besides the expression of non-polymorphic HLA-E and HLA-G molecules that are associated with immune tolerance, EVT also express highly polymorphic HLA-C molecules that can serve as targets for maternal dNK and CD8+ dT responses. HLA-C expression by EVT has a dual role as the main molecule to which immune tolerance needs to be established and as the only molecule that can present pathogen-derived peptides and provide protective immunity when EVT are infected. The focus of this review is to address the regulation of cytotoxicity of dNK and CD8+ dT, which is essential for maternal-fetal immune tolerance as well as recent evidence that both cell types can provide immunity to infections at the maternal-fetal interface. A particular emphasis is given to the role of HLA-C expressed by EVT and its capacity to elicit dNK and CD8+ dT responses. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
机译：为了建立健康怀孕，母体免疫系统必须耐受胎儿血糖抗原，但仍然有能力响应感染。蜕膜NK细胞（DNK）促进胎儿外向性滋养细胞（EVT）和胎盘生长的迁移以及EVT促进免疫耐受的能力是高兴趣和广泛研究的主题。然而，DNK和蜕膜CD8 + T细胞（CD8 + DT）如何对胎盘感染的影响以及调节其细胞溶解功能的机制远远忽略了抗扰度。胎儿EVT是胎盘中最侵入的细胞，并在该母形界面上直接与母体蜕膜免疫细胞相互作用。除了与免疫耐受相关的非多晶型HLA-E和HLA-G分子的表达之外，EVT还表达了高度多态性HLA-C分子，其可以作为母体DNK和CD8 + DT反应的靶标。 EVT的HLA-C表达具有双重作用，作为需要建立免疫耐受的主要分子，并且当EVT感染时可以提供病原体衍生的肽的唯一分子并提供保护性免疫。本综述的重点是解决DNK和CD8 + DT的细胞毒性调节，这对于母体免疫耐受性以及最近的证据表明，最近的次要表现可以为母体界面的感染提供免疫感。特别强调EVT表达的HLA-C的作用及其引发DNK和CD8 + DT反应的能力。 （c）2016 Elsevier Ireland Ltd.保留所有权利。

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