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首页> 外文期刊>Journal of Reproductive Immunology >Associations between fetal HLA-G genotype and birth weight and placental weight in a large cohort of pregnant women - Possible implications for HLA diversity
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Associations between fetal HLA-G genotype and birth weight and placental weight in a large cohort of pregnant women - Possible implications for HLA diversity

机译：胎儿HLA-G基因型与出生体重与孕妇队队的胎盘重量之间的关联 - 对HLA多样性的可能影响

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Birth weight and placental weight are crucial parameters for the survival of fetuses and newborns in mammals. High variation in the MHC is important for an effective adaptive immune response. The maternal immune system must be controlled in relation to the semi-allogenic fetus. The immunoregulatory HLA/MHC class Ib gene, HLA-G, is strongly expressed on extravillous trophoblast cells. We investigated birth weight and placental weight of the newborns in mothers heterozygous for an HLA-G 14 bp insertion (Ins)/deletion (Del) gene polymorphism. Separate analyses for pregnancies without preeclampsia (n = 185), pregnancies complicated by preeclampsia (n =101), and both groups combined, were performed. Interestingly, we observed the highest mean birth weight and placental weight in homozygous 14 by Del/Del newborns, and the lowest in 14 by Ins/Ins newborns (P = 0.008 and P = 0.009). The 14 by Del/Del genotype is also associated with high expression of HLA-G on the trophoblast membrane. In theory, fetuses and newborns with intermediate weights and sizes would be an optimal compromise for both the fetus/father and the mother compared with very high and low weights. If such fetuses/newborns more often are heterozygous at the HLA-G gene locus, then newborns with two distinct HLA haplotypes are favored, leading to a higher degree of HLA diversity. The results of the study may indicate that a compromise between an intermediate birth weight and placental weight, induction of maternal tolerance by a fetal-derived non-polymorphic HLA class lb molecule, and favoring of HLA heterozygous offspring, have evolved in humans. (C) 2017 Elsevier B.V. All rights reserved.
机译：出生体重和胎盘重量是哺乳动物胎儿和新生儿的生存的关键参数。 MHC的高变异对于有效的自适应免疫应答是重要的。母体免疫系统必须与半同种异体胎儿进行控制。免疫调节HLA / MHC类IB基因，HLA-G在外侧滋养细胞上强烈表达。我们在HLA-G 14bp插入（INS）/缺失（Del）基因多态性中，在母亲杂合中调查了新生儿的出生体重和胎盘重量。进行没有预填种（n = 185）的妊娠的单独分析，妊娠妊娠（n = 101）和两个组合组合的妊娠。有趣的是，我们在德尔/德新生儿观察纯合14中的最高平均出生体重和胎盘重量，并通过INS / INS Newwarns的最低（P = 0.008和P = 0.009）。 Del / Del基因型的14也与滋养板上的HLA-G的高表达相关。理论上，具有中间重量和尺寸的胎儿和新生儿将是胎儿/父亲和母亲的最佳折衷，而胎儿和母亲与非常高和低的重量相比。如果这种胎儿/新生儿更常常在HLA-G基因位于杂合子中杂合，则新生儿有两个不同的HLA单倍型，引起更高程度的HLA多样性。该研究的结果可能表明中性出生体重和胎盘重量之间的折衷，胎儿衍生的非多晶型HLA类IB分子诱导母体耐受，以及HLA杂合后代的偏好，已经进化在人体中。 （c）2017 Elsevier B.v.保留所有权利。

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