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首页> 外文期刊>Journal of Reproductive Immunology >The decidua of preeclamptic-like BPH/5 mice exhibits an exaggerated inflammatory response during early pregnancy
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The decidua of preeclamptic-like BPH/5 mice exhibits an exaggerated inflammatory response during early pregnancy

机译：初始羊皮类BPH / 5小鼠的DeCidua在怀孕期间表现出夸张的炎症反应

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摘要

Preeclampsia is a devastating complication of pregnancy characterized by late-gestation hypertension and proteinuria. Because the only definitive treatment is delivery of the fetus and placenta, preeclampsia contributes to increased morbidity and mortality of both mother and fetus. The BPH/5 mouse model, which spontaneously develops a syndrome strikingly similar to preeclampsia, displays excessive inflammation and suppression of inflammation improves pregnancy outcomes. During early pregnancy, decidual macrophages play an important role in promoting maternal tolerance to fetal antigens and regulating tissue remodeling, two functions that are critical for normal placental development. BPH/5 pregnancies are characterized by abnormal placentation; therefore, we hypothesized that macrophage localization and/or function is altered during early pregnancy at the site of placental formation (the decidua) compared to C57BL/6 controls. At early gestation time points, before the onset of maternal hypertension or proteinuria, there was a reduction in the number of macrophages in BPH/5 decidua and a concomitant increase in activated T cells compared with C57BL/6. BPH/5 decidua also exhibited decreased expression of the immunosuppressive cytokine, IL-10, and increased expression of pro inflammatory, inducible nitric oxide synthase. Together, these data suggest that a reduction in decidual macrophages during pregnancy is associated with immune activation in BPH/5 mice, inadequate placental development and may contribute to adverse pregnancy outcomes in this model.
机译：预口局部是怀孕的毁灭性并发症，其特征是晚期妊娠高血压和蛋白尿。由于唯一的定义治疗是胎儿和胎盘的递送，因此预口普拉姆斯有助于增加母亲和胎儿的发病率和死亡率。 BPH / 5小鼠模型自发地发展着与Preclampsia相似的综合征，显示出过度的炎症和抑制炎症改善了妊娠结果。在妊娠早期期间，蜕膜巨噬细胞在促进胎儿抗原和调节组织重塑的母体耐受性方面发挥着重要作用，这两个功能对于正常胎盘开发至关重要。 BPH / 5怀孕的特点是寄养异常;因此，我们假设巨噬细胞定位和/或功能在胎盘形成部位（DeCidua）的早期怀孕期间改变，与C57BL / 6对照相比。在早期妊娠时间点，在母体高血压或蛋白尿开始之前，BPH / 5 DeCidua的巨噬细胞数量减少，与C57BL / 6相比，活化T细胞的伴随增加。 BPH / 5 DeCidua还表现出免疫抑制细胞因子，IL-10和促炎诱导型一氧化氮合酶的增加表达的表达。这些数据在一起表明怀孕期间的蜕膜巨噬细胞的减少与BPH / 5小鼠的免疫激活有关，胎盘发育不足，可能有助于该模型的不利妊娠结果。

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  • 来源
    《Journal of Reproductive Immunology》 |2017年第2017期|共7页
  • 作者

    Heyward C. Y.; Sones J. L.; Lob H. E.; Yuen L. C.; Abbott K. E.; Huang W.; Begun Z. R.; Butler S. D.; August A.; Leifer C. A.; Davisson R. L.;

  • 作者单位

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Microbiol &

    Immunol Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Microbiol &

    Immunol Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Microbiol &

    Immunol Coll Vet Med Ithaca NY 14853 USA;

    Cornell Univ Dept Biomed Sci Coll Vet Med Ithaca NY 14853 USA;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 妇科学;
  • 关键词

    Macrophages; T cells; iNOS; IL-10; Tolerance;

    机译：巨噬细胞;T细胞;INOS;IL-10;耐受性;

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