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首页> 外文期刊>Journal of Reproductive Immunology >Unsaturated fatty acids protect trophoblast cells from saturated fatty acid-induced autophagy defects
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Unsaturated fatty acids protect trophoblast cells from saturated fatty acid-induced autophagy defects

机译：不饱和脂肪酸保护来自饱和脂肪酸诱导的自噬缺陷的滋养细胞

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Dysregulated serum fatty acids are associated with a lipotoxic placental environment, which contributes to increased pregnancy complications via altered trophoblast invasion. However, the role of saturated and unsaturated fatty acids in trophoblastic autophagy has yet to be explored. Here, we demonstrated that prolonged exposure of saturated fatty acids interferes with the invasiveness of human extravillous trophoblasts. Saturated fatty acids (but not unsaturated fatty acids) inhibited the fusion of autophagosomes and lysosomes, resulting in the formation of intracellular protein aggregates. Furthermore, when the trophoblast cells were exposed to saturated fatty acids, unsaturated fatty acids counteracted the effects of saturated fatty acids by increasing degradation of autophagic vacuoles. Saturated fatty acids reduced the levels of the matrix metalloproteinases (MMP)-2 and MMP-9, while unsaturated fatty acids maintained their levels. In conclusion, saturated fatty acids induced decreased trophoblast invasion, of which autophagy dysfunction plays a major role.
机译：失调的血清脂肪酸与脂毒性胎盘环境有关，这有助于通过改变的滋养细胞侵袭增加妊娠并发症。然而，饱和和不饱和脂肪酸在滋养细胞自噬中的作用尚未探索。在这里，我们证明了饱和脂肪酸的长期暴露会干扰人外向性滋养管的侵袭性。饱和脂肪酸（但不是不饱和脂肪酸）抑制自噬体和溶酶体的融合，导致细胞内蛋白质聚集体的形成。此外，当滋养细胞暴露于饱和脂肪酸中时，不饱和脂肪酸通过增加自噬瓦耐力的降解来抵消饱和脂肪酸的作用。饱和脂肪酸降低了基质金属蛋白酶（MMP）-2和MMP-9的水平，而不饱和脂肪酸保持其水平。总之，饱和脂肪酸诱导滋养细胞侵袭下降，其中自噬功能障碍起着重要作用。

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