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首页> 外文期刊>Journal of Reproductive Immunology >Effect of polybrominated diphenyl ether congeners on placental cytokine production
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Effect of polybrominated diphenyl ether congeners on placental cytokine production

机译：聚溴二苯基醚同型对胎盘性细胞因子生产的影响

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Polybrominated diphenyl ethers (PBDEs) are pollutants that may increase the risk of preterm birth. In previous studies, we found that a mixture of PBDEs altered the expression of biomarkers for preterm birth by the placenta. However, there are 209 different PBDE congeners with different tissue distributions. How these different congeners may alter the production of immunomodulators by the placenta that help to maintain the survival of the fetal allograft is unclear. Therefore, we compared the effects 5 common congeners on basal and bacteria-stimulated cytokine production by the placenta. Placental explant cultures were incubated with 20 mu M of PBDE congeners 47, 99, 100, 153, 209 or vehicle in the presence and absence of Escherichia coli for 20 h. Conditioned medium was harvested and concentrations of IL-1 beta, TNF-alpha, IL-6, sgp130, HO-1, IL-10, BDNF, and 8-IsoP quantified. For unstimulated cultures, all congeners, except for PBDE-47, reduced the production of IL-1 beta and IL-6 production was enhanced by PBDE-153. BDNF concentrations tended to be reduced by most PBDE congeners and IL-10 production was enhanced by PBDE-99, -153, and -209. 8-IsoP production was enhanced by PBDE-153, but not the other congeners. For bacteria-stimulated cultures, PBDE-47 increased IL-1 beta production and PBDE-47, -153, and -209 tended to reduce TNF-a production. IL-6 production was enhanced by all PBDEs except 153, IL-10 production was enhanced by all congeners except for PBDE-47. All congeners significantly enhanced BDNF and 8-IsoP. These results suggest that PBDEs can alter the expression of placental biomarkers in a congener and infection-dependent manner.
机译：多溴二苯醚（PBDES）是可能增加早产的风险的污染物。在以前的研究中，我们发现PBDES的混合物改变了胎盘的早产的生物标志物的表达。然而，有209种不同的PBDE同志，具有不同的组织分布。这些不同的Congeners如何通过胎盘改变免疫调节剂的产生，有助于保持胎儿同种异体移植物的存活率尚不清楚。因此，我们将5种常见的Congeners对基底和细菌刺激的细胞因子产生的影响进行了比较。在存在和不存在大肠杆菌的情况下，将胎盘外部培养物与20μm的PBDE同学47,99,100,153,209或载体一起温育20小时。收获条件培养基并浓度IL-1β，TNF-α，IL-6，SGP130，HO-1，IL-10，BDNF和8-ISOP定量化。对于未刺激的培养物，除了PBDE-47之外的所有Congeners，通过PBDE-153增强了IL-1β和IL-6产生的产生的产量。通过PBDE-99，-153和-209，增强了大多数PBDE同志和IL-10产生的BDNF浓度趋于减少。 PBDE-153增强了8-ISOP生产，但不是另一个同义因素。对于细菌刺激的培养物，PBDE-47增加IL-1β生产和PBDE-47，-153和-209倾向于降低TNF-A生产。除了PBDE-47外，所有PBDE，所有PBDE都会增强IL-6生产，除了PBDE-47，所有的CONGENS都会增强IL-10。所有Congeners都显着增强了BDNF和8 ISOP。这些结果表明，PBDES可以以同一种和感染依赖性方式改变胎盘生物标志物的表达。

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