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首页> 外文期刊>Journal of Reproductive Immunology >Annexin A1, FPR2/ALX, and inflammatory cytokine expression in peritoneal endometriosis
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Annexin A1, FPR2/ALX, and inflammatory cytokine expression in peritoneal endometriosis

机译：腹膜子宫内膜异位症的膜蛋白A1，FPR2 / ALX和炎性细胞因子表达

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摘要

To characterize Annexin A1 (ANXA1), FPR2/ALX and cytokines expression in peritoneal endometriosis and to clarify their role in its etiology, a cross-sectional study was performed with forty women in reproductive age (22 patients with endometriosis and 18 control women) that had undergone laparoscopic surgery. Peritoneal biopsy and fluid aspirations from endometriosis and control samples were analyzed for the expression of ANXA1, FPR2/ ALX and cytokines. ANXA1 and FPR2 / ALX levels were measured by Western blotting and interleukin 1 beta (IL-1 beta), interleukin 4 (IL-4), interleukin 6 (IL-6), and interleukin 10 (IL-10) levels were quantified by enzyme-linked immunosorbent assay (ELISA). The present study identified the presence in human peritoneal tissue of ANXA1 and FPR2 / ALX both in healthy condition and in women with peritoneal endometriosis, however, was lower in endometriosis samples than in control samples. By quantifying the IL-6 and IL-1 beta cytokines in the peritoneal fluid by ELISA, this study identified a higher IL-6 concentration in endometriosis group, but no significative difference in IL-1 beta levels. The IL-4 and IL-10 levels could not be detected.
机译：为了表征Annexin A1（ANXA1），FPR2 / ALX和细胞因子表达在腹膜子宫内膜异位症中，并在其病因中阐明其作用，在生殖年龄（22例子宫内膜异位症和18名控制妇女）进行横截面研究经历了腹腔镜手术。分析了来自子宫内膜异位症和对照样品的腹膜活检和流体抱负，用于ANXA1，FPR2 / ALX和细胞因子的表达。通过蛋白质印迹和白细胞介素1β（IL-1β），白细胞介素4（IL-4），白细胞介素6（IL-6）和白细胞介素10（IL-10）水平测量ANXA1和FPR2 / ALX水平。通过酶联免疫吸附试验（ELISA）。本研究鉴定了在治疗病症和腹膜子宫内膜异位症的妇女的人类腹膜组织中存在的存在，但是子宫内膜异位症样品中的患者较低，而不是对照样品。通过ELISA量化腹膜液中的IL-6和IL-1β细胞因子，本研究确定了子宫内膜异位荧光病组中的较高IL-6浓度，但IL-1β水平没有明显的差异。无法检测到IL-4和IL-10水平。

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