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首页> 外文期刊>Journal of renal nutrition: the official journal of the Council on Renal Nutrition of the National Kidney Foundation >A Randomized Controlled Trial of an Intensive Nutrition Intervention Versus Standard Nutrition Care to Avoid Excess Weight Gain After Kidney Transplantation: The INTENT Trial
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A Randomized Controlled Trial of an Intensive Nutrition Intervention Versus Standard Nutrition Care to Avoid Excess Weight Gain After Kidney Transplantation: The INTENT Trial

机译：随机对照试验的强化营养干预与标准营养治疗，以避免肾移植后的体重增加：意图试验

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ObjectiveExcessive weight gain is common after kidney transplantation and increases cardiovascular risk. The aim of this randomized controlled trial was to determine whether an intensive nutrition and exercise intervention delivered alongside routine post-transplant care would reduce post-transplant weight gain. DesignSingle-blind, randomized controlled trial. Subjects and SettingAdult kidney transplant recipients at a regional transplant center were recruited during routine outpatient clinic visits in the first month after transplant. Patients with a body mass index >40?kg/m2or <18.5?kg/m2, severe malnutrition, or ongoing medical complications were excluded. InterventionParticipants were randomized to intensive nutrition intervention (individualized nutrition and exercise counselling; 12 dietitian visits; 3 exercise physiologist visits over 12?months) or to standard nutrition care (guideline based; 4 dietitian visits). Main outcome measuresThe primary outcome was weight at 6?months after transplant adjusted for baseline weight, obesity, and gender, analyzed using analysis of covariance. The secondary outcomes included body composition, biochemistry, quality of life, and physical function. ResultsThirty-seven participants were randomized to the intensive intervention (n?=?19) or to standard care (n?=?18); one intensive group participant withdrew before baseline. Weight increased between baseline, 6 and 12?months (78.0?±?13.7 [standard deviation], 79.6?±?13.0?kg, 81.6?±?12.9?kg; mean change 4.6%P?
机译：肾移植后，目的意义重量增加并增加心血管风险。这种随机对照试验的目的是确定与常规移植后护理的密集营养和运动干预是否会降低移植后的重量增益。设计盲目，随机对照试验。在移植后的第一个月的常规门诊诊所访问期间招募了区域移植中心的受试者和CarrowAdull肾移植受者。体重指数患者> 40？kg / m201. kg / m2，严重营养不良或正在进行的医疗并发症被排除在外。介入髌醛随机化以密集的营养干预（个性化营养和运动咨询; 12次营养师访问; 3个运动生理学家访问12多个月）或标准营养护理（基于指南; 4课程访问）。主要结果测量主要结果在6月6日的重量为基线重量，肥胖和性别的移植后，分析使用协方差分析进行分析。二次结果包括身体成分，生物化学，生活质量和物理功能。结果大七参与者被随机分配到密集的干预（n？=？19）或标准护理（n？=？18）;一个密集的集团参与者在基线之前退出。基线，6和12之间的重量增加？月份（78.0？±13.7 [标准偏差]，79.6？±13.0？kg，81.6？±12.9Ωkg;平均变化4.6％p？<001）但在6？几个月在组之间没有显着差异：77.0？±12.4 kg（密集）; 82.2？±13.4？kg（标准）;调整后的差异为0.4？kg（95％置信区间：？2.2至3.0？kg）;分析Covariancep？= ?. 7。没有观察到次要结果的组间差异。整个群组，总体蛋白质和物理功能（步态速度，坐在支架，握力强度，身体活动和生活质量[全部除了2个域]）改善。然而，对于全身体脂，HBA1C和跨越队列的空腹葡萄糖，可以看到不利的变化。结论在移植后的第一年内移植受试者与标准营养照顾相比，移植后的第一年没有受益，尽管两组体重增加相对适中。

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