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Energy balance in predialysis patients on a low-protein diet.

机译:在低蛋白质饮食中预析性患者的能量平衡。

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OBJECTIVE: To determine if energy intake on a low-protein diet (0.6 g protein/kg ideal body weight (ibw)/d) with 70% animal protein (Diet A) or 30% animal protein (Diet B) meets energy expenditure derived from measured resting energy expenditure and activity levels. DESIGN: Patients already on a conventional low-protein diet with 70% animal protein kept a 5-day weighed dietary intake, with a 3-day activity diary, and had their resting metabolic rate (RMR) measured. Patients then switched to a diet with 30% animal protein for a minimum of 2 weeks (range, 2 to 16 weeks) and repeated the weighed intake and RMR measurement. SETTING: Predialysis hospital outpatients. PATIENTS: Seven patients were recruited, 5 male. Mean age, 56 years (range, 43 to 78 years); mean serum creatinine 300 micromol/L (range, 180 to 560 micromol/L). INTERVENTION: Indirect calorimetry used to measure RMR. MAIN OUTCOME MEASURE: RMR compared with standard formulae and total energy expenditure compared with dietary intake. RESULTS: Mean RMR was 5.76 MJ/d (1,385 kcal/d) or 84.9 kJ/kg ibw/d (20.3 kcal/kg ibw/d); which was 108% to 113% of that predicted by standard formulae. Total energy expenditure (RMR plus activity) was 8.35 MJ/d (1,996 kcal/d) or 123.3 kJ/kg/d (29.5 kcal/kg ibw/d). Mean energy intake was 116.3 (27.8 kcal/kg ibw/d) on Diet A and 131.2 (31.4 kcal/kg ibw/d) on Diet B (P = .096) with 3 of the 7 patients meeting their energy expenditure on Diet A and 4 on Diet B. CONCLUSION: RMR of patients with chronic renal failure is within expected range for healthy individuals, and the activity of these relatively fit patients similar to healthy individuals with light to moderate activity. Energy intake on the low-protein diets failed to meet energy expenditure in 4 patients on Diet A and 3 patients on Diet B. Low energy intake may contribute to the development of malnutrition in some patients.
机译:目的:确定是否对低蛋白质饮食的能量摄入(0.6g蛋白/ kg理想体重(Ibw)/ d),70%动物蛋白(饮食a)或30%动物蛋白(饮食b)符合衍生的能源支出从测量的休息能源支出和活动水平。设计:患有常规低蛋白质饮食的患者,70%的动物蛋白质保持5天称重膳食摄入,具有3天的活动日记,并测量其静止的代谢率(RMR)。然后患者用30%的动物蛋白质切换到饮食至少2周(范围,2至16周)并重复称重的摄入和RMR测量。环境:预选医院门诊。患者:招募了7名患者,5名雄性。平均年龄,56岁(范围,43至78岁);平均血清肌酐300μm微溶剂/ L(范围,180至560微米/ L)。干预:用于测量RMR的间接量热法。主要结果措施:与膳食摄入相比,RMR与标准公式和总能源开支相比。结果:平均RMR为5.76 MJ / D(1,385 kcal / d)或84.9 kJ / kg Ibw / d(20.3 kcal / kg ibw / d);这是标准公式预测的108%至113%。总能源支出(RMR加活性)为8.35 MJ / D(1,996千卡/ d)或123.3 kJ / kg / d(29.5 kcal / kg ibw / d)。饮食A和131.2(31.4 kcal / kg Ibw / d)的平均能量摄入量为116.3(27.8 kcal / kg Ibw / d),饮食b(p = .096),7名患者中有3名达到其饮食的能源支出4关于饮食B.结论:慢性肾功能衰竭的患者的RMR在预期的健康个体范围内,这些相对适合患者的活动与较轻的健康个体相似。低蛋白质饮食的能量摄入未能满足4例饮食A和3例饮食B的能​​源支出。低能量摄入可能导致一些患者的营养不良的发展。

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