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首页> 外文期刊>Journal of renal nutrition: the official journal of the Council on Renal Nutrition of the National Kidney Foundation >Cross-sectional relationship between dietary protein and energy intake, nutritional status, functional status, and comorbidity in older versus younger hemodialysis patients.
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Cross-sectional relationship between dietary protein and energy intake, nutritional status, functional status, and comorbidity in older versus younger hemodialysis patients.

机译:较年轻的血液透析患者膳食蛋白质和能量摄入,营养状况,功能状态和合并症之间的横截面关系。

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OBJECTIVE: To evaluate the dietary energy intakes (DEI) and dietary protein intakes (DPI) of older (> or = 65 years), middle-aged (50 to 64 years), and younger (< 50 years) maintenance hemodialysis patients enrolled in the Hemodialysis (HEMO) Study, and to describe the relationship between age, nutritional status, functional status, and comorbidity. DESIGN: A cross-sectional analysis of the first 1,397 participants in baseline (before randomization) was performed. MAIN OUTCOME MEASURES: DEI and DPI, serum albumin, creatinine, total cholesterol, normalized protein catabolic rate (nPCR), equilibrated nPCR (enPCR), functional status, and comorbidities. RESULTS: Mean DEI, DPI, serum albumin, creatinine, nPCR, and enPCR were significantly lower in the older compared with the younger patients, despite similar doses of dialysis as measured by equilibrated Kt/V. Mean DEI, DPI, nPCR, and enPCR were not significantly different between the middle-aged and older patients, whereas albumin and creatinine were significantly lower in the older patients. Mean dry weight and percent of standard body weight in the younger and older patients were similar. In all groups, mean DEI was lower than both the HEMO study's standard of care (SOC) and the Kidney Disease Outcomes Quality Initiative (K/DOQI) nutrition recommendations, whereas mean DPI was lower than the SOC and K/DOQI recommendations only in the middle-aged and older patients. Middle-aged and older patients had higher cholesterol, lower functional status, and more comorbidities than the younger patients. CONCLUSION: Middle-aged and older maintenance dialysis patients may be at greater risk for developing protein-energy malnutrition than their younger counterparts. Inadequate DEI and DPI reported in middle-aged and older patients were associated with lower levels of biomarkers of nutritional status, lower functional status, and higher comorbidities than in the younger patients.
机译:目的:评价较旧(>或= 65岁),中年(50至64岁)的膳食能量摄入量(DEI)和膳食蛋白摄入量(50至64岁),更年轻(<50岁)维持血液透析患者血液透析(HEMO)研究,并描述年龄,营养状况,功能状态和合并症之间的关系。设计:进行基线(在随机化之前)的前1,397名参与者的横截面分析。主要观察指标:DEI和DPI,血清白蛋白,肌酐,总胆固醇,归一化蛋白分解代谢率(NPCR),平衡的NPCR(ENPCR),功能状态和合并症。结果:与较年轻的患者相比,平均dei,DPI,血清白蛋白,肌酐,NPCR和EnPCR在较年轻的患者中显着降低,尽管通过平衡的Kt / v测量了类似剂量的透析剂量的透析。中年患者与年龄和老年患者之间的平均dei,DPI,NPCR和enPCR在显着差异,而白蛋白和肌酐在老年患者中显着降低。在年轻和老年患者中平均干重和标准体重的百分比相似。在所有群体中,平均dei低于Hemo研究的护理标准(SoC)和肾病成果质量倡议(K / Doqi)营养建议,而平均dpi则低于SoC和K / Doqi建议中年和老年患者。中年和老年患者的胆固醇具有更高的胆固醇,功能性降低,并且比较年轻的患者更高的合并症。结论:中年和较老的维持透析患者可能对蛋白质能量营养不良的风险更大,而不是较年轻的对应物。中老年患者报告的DEI和DPI不足与营养状况,较低功能状况和更高的患者较低的生物标志物较低的生物标志物相关。

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