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首页> 外文期刊>Alimentary pharmacology & therapeutics. >Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy.
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Meta-analysis: the effect of supplementation with probiotics on eradication rates and adverse events during Helicobacter pylori eradication therapy.

机译：荟萃分析：补充益生菌对幽门螺杆菌根除治疗期间根除率和不良事件的影响。

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BACKGROUND: Recent evidence found probiotics could inhibit Helicobacter pylori colonization from both in vitro and in vivo studies. AIM: To systematically evaluate whether adding probiotics to anti-H. pylori regimens could improve eradication rates and reduce side effects during anti-H. pylori treatment. METHODS: Eligible articles were identified by searches of electronic databases. We included all randomized trials comparing probiotics supplementation to placebo or no treatment during anti-H. pylori regimens. Statistical analysis was performed with Review Manager 4.2.8. Subanalysis/Sensitivity analysis was also performed. RESULTS: We identified 14 randomized trials (n = 1671). Pooled H. pylori eradication rates were 83.6% (95% CI = 80.5-86.7%) and 74.8% (95% CI = 71.1-78.5%) for patients with or without probiotics by intention-to-treat analysis, respectively, the odds ratio (OR) was 1.84 (95% CI = 1.34-2.54); the occurrence of total side effects were 24.7% (95% CI = 20.0-29.4%) and 38.5% (95% CI = 33.0-44.1%) for groups with or without probiotics, especially for diarrhoea, the summary OR was 0.44 (95% CI = 0.30-0.66). CONCLUSIONS: Our review suggests that supplementation with probiotics could be effective in increasing eradication rates of anti-H. pylori therapy, and could be considered helpful for patients with eradication failure. Furthermore, probiotics show a positive impact on H. pylori therapy-related side effects.
机译：背景：最近的证据表明，益生菌可以通过体外和体内研究抑制幽门螺杆菌定植。目的：系统评估是否在抗H中添加了益生菌。幽门螺杆菌疗法可以提高根除率并减少抗H期间的副作用。幽门螺杆菌治疗。方法：通过搜索电子数据库来确定合格的文章。我们纳入了所有随机试验，比较了在抗H期间将益生菌补充剂与安慰剂或未治疗的比较。幽门螺旋杆菌疗法。使用Review Manager 4.2.8进行统计分析。还进行了亚分析/灵敏度分析。结果：我们鉴定了14项随机试验（n = 1671）。通过意向性治疗分析，有或没有益生菌患者的合并幽门螺杆菌根除率分别为83.6％（95％CI = 80.5-86.7％）和74.8％（95％CI = 71.1-78.5％）比（OR）为1.84（95％CI = 1.34-2.54）;对于有或没有益生菌的组，尤其是腹泻组，总的副作用发生率为24.7％（95％CI = 20.0-29.4％）和38.5％（95％CI = 33.0-44.1％），总OR为0.44（95 ％CI = 0.30-0.66）。结论：我们的评论表明，补充益生菌可以有效提高根除H的效率。幽门螺杆菌疗法，可能被认为对根除失败的患者有帮助。此外，益生菌对幽门螺杆菌治疗相关的副作用有积极影响。

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