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首页> 外文期刊>Journal of solid state electrochemistry >An convenient strategy for IgG electrochemical immunosensor: the platform of topological insulator materials Bi2Se3 and ionic liquid
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An convenient strategy for IgG electrochemical immunosensor: the platform of topological insulator materials Bi2Se3 and ionic liquid

机译：IgG电化学免疫传感器的方便策略：拓扑绝缘材料Bi2Se3和离子液体平台

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摘要

A substantial outstanding challenge in diagnostics and disease monitoring is the ability to assay rapidly and conveniently for protein biomarkers within complex biological media. Bi2Se3, as an important topological insulator (TI) material, was synthesized by a solvothermal method and characterized structurally. Subsequently, the composite of Bi2Se3 and ionic liquid ([BMIm]BF4 IL) was used as a sensing interface to cross-link goat anti-human immunoglobulin G (anti-IgG) via glutaraldehyde (GA) to fabricate an Bi2Se3/IL/GA/anti-IgG-carbon paste electrode (CPE). The nonspecific binding sites were enclosed with bovine serum albumin (BSA) to develop a label-free IgG immunosensor. The result showed that the proposed label-free IgG immunosensor exhibited high specificity with a detection limit of 0.8 ng mL(-1) and linear range from 2 to 300, and 300 to 2200 ng mL(-1). Besides, the immunosensor exhibited high specificity for IgG detection, acceptable reproducibility, and stability. Thus, the strategy reported here paved a simple way to design a sensitive and cost-effective sensing platform for extension to other disease biomarkers.
机译：诊断和疾病监测中的大量出色挑战是在复杂生物介质中迅速和方便地进行蛋白质生物标志物的能力。作为重要的拓扑绝缘体（Ti）材料Bi2Se3通过溶剂质方法合成并在结构上表征。随后，将Bi2Se3和离子液体（[Bmim] BF4 IL）的复合物用作通过戊二醛（GA）通过戊二醛（GA）通过戊二醛（GA）来制造Bi2Se3 / IL / GA的传感界面。 /抗IgG-碳浆料电极（CPE）。用牛血清白蛋白（BSA）封闭非特异性结合位点，以产生无标记的IgG免疫传感器。结果表明，所提出的无标签IgG免疫传感器表现出高特异性，检测极限为0.8ng ml（-1），线性范围为2至300，300至2200ng ml（-1）。此外，免疫传感器对IgG检测，可接受的再现性和稳定性表现出高特异性。因此，这里报道的战略铺设了一种简单的方法来设计敏感和经济有效的传感平台，以便延伸到其他疾病生物标志物。

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