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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association of Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism with the Risk of Atherosclerosis
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Association of Angiotensin-Converting Enzyme Insertion/Deletion Polymorphism with the Risk of Atherosclerosis

机译：血管紧张素转换酶插入/缺失多态性与动脉粥样硬化风险的关联

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Aims: The objective of this study was to perform a meta-analysis to evaluate the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and susceptibility to atherosclerosis (AS). Methods: MEDLINE, EMBASE, and the ISI Web of Science were searched for all eligible published studies concerning the relationship of ACE gene polymorphism with AS without language restrictions. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to evaluate this relationship under different genetic models using meta-analytic methods. Results: A total of 15 articles (16 studies) were involved in this meta-analysis. The D allele of the ACE gene had a nonsignificant increase in the risk of AS (D versus I: OR = 1.23, 95% CI,.98-1.53, P = .07; I-2 = 87.2%, P-heterogeneity < .01). Compared with the II genotype, the DI (relative risk [RR]: 1.35, 95% CI: 1.09, 1.67, P < .01; I-2 = 47.8%, P-heterogeneity = .017) and (DD + DI) (RR = 1.38, 95% CI: 1.04, 1.82, P = .02; I-2 = 73.3%, P-heterogeneity < .01) genotype of ACE was associated with higher risk of AS, respectively. Subjects with the DD genotype showed a statistically nonsignificant trend toward greater risk of AS (RR = 1.53, 95% CI:.97, 2.43, P = .07; I-2 = 88.6%, P-heterogeneity < .01). Further subgroup analyses showed that significant relationships were only found in Europeans under different gene polymorphism or different genotype models rather than Asians. Conclusions: The present meta-analysis indicated that the D allele in the ACE gene was associated with the risk of AS, especially in Europeans. Furthermore, increased copy number of D allele was significantly associated with increased AS risk in a dose-dependent manner.
机译：目的：本研究的目的是进行荟萃分析，以评估血管紧张素转换酶（ACE）基因插入/缺失（I / D）多态性和对动脉粥样硬化的易感性（AS）之间的关联。方法：搜索Medline，Embase和ISI科学网络的所有符合条件的发布研究，根据ACE基因多态性与没有语言限制的关系。汇集了具有95％置信区间（CIS）的汇集的差距（或），以评估使用Meta-Analytic方法在不同遗传模型下的这种关系。结果：该荟萃分析共有15篇（16项研究）。 ACE基因的D等位基因因（D与I e：OR = 1.23,95％CI，0.98-1.53​​，P = .07; I-2 = 87.2％，P-异质性< .01）。与II基因型相比，DI（相对风险[RR]：1.35,95％CI：1.09,1.67，P <.01; I-2 = 47.8％，P-异质性= .017）和（DD + DI） （RR = 1.38,95％CI：1.04,1.82，p = .02; I-2 = 73.3％，澳元的基因型分别与较高风险相关。具有DD基因型的受试者显示出统计学上不切实际的趋势（RR = 1.53,95％CI：.97,2.43，P = .07; I-2 = 88.6％，P-异质性<.01）。进一步的亚组分析表明，在不同基因多态性或不同基因型模型中的欧洲人或不同的基因型模型而不是亚洲人的欧洲人中仅发现了显着的关系。结论：目前的荟萃分析表明，ACE基因中的等位基因与欧洲人的风险有关。此外，随着剂量依赖性方式增加，D等位基因的拷贝数显着相关。

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