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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Hematoma Expansion of Intracerebral Hemorrhage
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Magnetic Resonance Imaging Markers of Cerebral Small Vessel Disease in Hematoma Expansion of Intracerebral Hemorrhage

机译：脑出血血肿扩增脑小血管病的磁共振成像标记

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Background: Hematoma expansion is an independent risk factor of unfavorable outcome after intracerebral hemorrhage (ICH), which always occurs in the early phase after symptoms onset. The relationship between underlying small vessel disease (SVD) and hematoma expansion was inconsistent in patients with ICH. We aimed to investigate the relationship between magnetic resonance (MR) characteristics of SVD and hematoma expansion in patients with ICH within 72 hours after symptoms onset. Methods: Data were derived from a cohort of biological sample collection from April 2014 to April 2016. We recruited patients aged 18 years or older with a baseline and follow-up computed tomography within 72 hours after symptom onset, as well as an MR imaging within 3 months before or after ICH. Hematoma expansion was defined as an increase in volume between baseline and final hematoma volume exceeding 6 mL or 33% of the baseline volume. Multivariate logistic regression was used to explore the association between clinical characteristics, imaging markers, total SVD score, and hematoma expansion in patients with ICH. Results: A total of 103 patients experienced hematoma expansion among the 263 enrolled patients (mean age 53.4 +/- 14.0 years, 76.4% male). Electrocardiogram abnormal rhythm, fewer non-lobar microbleeds, lower plasma homocysteine concentration, and smaller baseline hematoma volume independently predicted the risk of hematoma expansion (P = .004, .021, .001, and .024, respectively). Odds ratios ranged from 1.02 to 3.72. Conclusions: Our study suggested that the use of MR markers revealing underlying SVD may help to identify patients with ICH with potential hematoma expansion.
机译：背景：血肿膨胀是脑出血（ICH）后不利结果的独立危险因素，这在症状发作后一直发生在早期阶段。基础小血管疾病（SVD）和血液膨胀之间的关系在ICH患者中不一致。我们旨在探讨症状发作后72小时内患者患者磁共振（MR）特征的磁共振（MR）特征的关系。方法：从2014年4月到2016年4月，我们源自生物样品队列的数据。我们征聘了18岁或以上的患者，在症状发作后72小时内，在72小时内，在72小时内，以及在内心的成像在ICH之前或之后3个月。血肿膨胀定义为基线和最终血肿体积之间的体积增加超过6ml或33％的基线体积。用于探讨ICH患者临床特征，成像标志物，总SVD评分和血肿扩张之间的关联。结果：共有103名患者经历了263名患者的血肿扩张（平均年龄53.4 + -14.0岁，男性为76.4％）。心电图异常节律，非叶片微斑块，较低的血浆同型半胱氨酸浓度，较小的基线血肿体积独立地预测了血肿膨胀的风险（P = .004，.021，.021，.024分别）。赔率比率为1.02至3.72。结论：我们的研究表明，利用揭示潜在的SVD的MR标志物可能有助于鉴定具有潜在血肿扩张的ICH患者。

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