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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Computational Fluid Dynamics Analysis of Lateral Striate Arteries in Acute Ischemic Stroke Using 7T High-resolution Magnetic Resonance Angiography
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Computational Fluid Dynamics Analysis of Lateral Striate Arteries in Acute Ischemic Stroke Using 7T High-resolution Magnetic Resonance Angiography

机译：7T高分辨率磁共振血管造影急性缺血性脑卒中横向动脉的计算流体动力学分析

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Background: Infarcts in the lateral striate artery (LSA) territory can be caused by several pathological changes, including lipohyalinosis and microatheroma. However, fluid dynamic effects on these changes remain unknown. Thus, we investigated whether the fluid dynamic metrics of the LSAs were altered in patients with acute ischemic stroke using computational fluid dynamics (CFD) analysis. Methods: Fifty-one patients with acute ischemic stroke confined in the basal ganglia and/or corona radiata underwent high-resolution magnetic resonance angiography (HR-MRA) at 7T. We performed CFD analyses to obtain indices including the wall shear stress (WSS), WSS gradient (WSSG), and flow velocity (FV) and compared these values between the ipsilesional and contralesional sides in the patients with infarcts in the LSA or non-LSA territories. Results: In patients with LSA-territory infarcts, the WSS, WSSG, and FV values were significantly lower in the ipsilesional LSAs than in the contralesional LSAs (P=.01-.03), while these values in the proximal middle cerebral arteries showed no significant lateralities. In contrast, in patients with non-LSA-territory infarcts, there were no significant lateralities in the metrics between the ipsilesional and contralesional sides. Conclusions: The CFD analyses using HR-MRA revealed significantly low WSS and WSSG values of the ipsilesional LSAs compared with that of the contralesional side in patients with LSA-territory infarcts, suggesting that fluid dynamic factors of LSAs can be one of the risk factors for LSA-territory infarctions.
机译：背景：横向条纹动脉（LSA）境内的梗塞可能是由几种病理变化引起的，包括脂质化和微瘤。然而，对这些变化的流体动态效应仍然是未知的。因此，我们研究了使用计算流体动力学（CFD）分析的急性缺血性卒中患者改变了LSA的流体动态度量。方法：急性缺血性卒中患者局限于基底神经节和/或电晕弧菌在7T时接受高分辨率磁共振血管造影（HR-MRA）。我们执行了CFD分析以获得包括壁剪切应力（WSS），WSS梯度（WSSG）和流速（FV）的指数，并将这些值与LSA或非LSA中梗塞患者的Ipsilesional和禁区之间的这些值进行比较领土。结果：在LSA-域梗死的患者中，IPsiles LSA中的WSS，WSSG和Fv值显着低于对侧LSA（P = .01-.03），而近端中脑动脉的这些值显示出来没有重要的旁边。相比之下，在非LSA-境梗塞患者中，IPSiles和违反侧面之间的指标中没有重要的侧面。结论：使用HR-MRA的CFD分析显示，与LSA-TERTOTORY INFARCTS患者的持正侧的相对侧，揭示了IPsiles LSA的显着低的WSS和WSSG值，表明LSA的流体动态因素可以是风险因素之一LSA-境内呼吸。

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