...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >A Model to Prevent Fibrinolysis in Patients with Stroke Mimics
【24h】

A Model to Prevent Fibrinolysis in Patients with Stroke Mimics

机译：一种防止卒中模拟患者纤维蛋白溶解的模型

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: Many patients with stroke-mimicking conditions receive treatment with intravenous fibrinolysis (IVF), a treatment associated with potentially serious complications. We sought to determine if any clinical or radiographic characteristics can help predict stroke mimics among IVF candidates. Methods: This retrospective study was carried out at a single institution. Patients treated with intravenous re-combinant tissue plasminogen activator (rt-PA; n = 193) were divided into 3 categories: acute ischemic stroke (n = 142), aborted stroke (n = 21), and stroke mimics (n = 30). Analysis of variance and the chi-square test were used to assess differences, while logistic regression models were computed to predict groups. Results: Mimics treated with rt-PA did not experience complications (intracranial bleeding, systemic hemorrhage, or angioedema), and had better neurologic and functional outcomes than stroke patients (P < .05). Several variables helped differentiate strokes from mimics, including atherosclerosis on computed tomographic angiography (odds ratio [OR] 23.6; 95% confidence interval [CI] 8.4-66.2), atrial fibrillation (OR 11.4; 95% CI 1.5-86.3), age >50 years (OR 7.2; 95% CI 2.8-18.5), and focal weakness (OR 4.15; 95% CI 1.75-9.8). Other variables decreased chances of stroke: migraine history (OR 0.05; 95% CI 0.01-0.4), epilepsy (OR 0.13; 95% CI 0.02-0.8), paresthesia (OR 0.1; 95% CI 0.04-0.3), and precordialgia (OR 0.045; 95% CI 0.002-0.9). A regression model using focal weakness, computed tomographic angiography findings, and precordialgia had a 90.2% predictive accuracy. Conclusions: IVF has low complication rates in stroke mimics. Certain clinical characteristics appear predictive of stroke mimics, particularly normal computed tomographic angiography. If confirmed, this may help prevent giving IVF to patients without stroke.
机译：背景：许多中风模仿条件的患者接受静脉纤维蛋白溶解（IVF）治疗，一种与潜在严重并发症相关的治疗。我们试图确定是否有任何临床或射线照相特征可以帮助预测IVF候选者之间的中风模仿。方法：该回顾性研究是在一个机构进行的。用静脉内重组组织纤溶酶原激活剂（RT-PA; N = 193）治疗的患者分为3类：急性缺血性卒中（n = 142），中流程中风（n = 21），卒中模拟（n = 30） 。方差分析和Chi-Square测试评估差异，而计算逻辑回归模型以预测群体。结果：使用RT-PA治疗的模拟物没有经历并发症（颅内出血，全身出血或血管内膜），并且具有比中风患者的更好的神经系统和功能性结果（p <.05）。有几个变量有助于区分模拟物的中风，包括在计算机断层血管造影的动脉粥样硬化（几率比[或] 23.6; 95％置信区间[CI] 8.4-66.2），心房颤动（或11.4; 95％CI 1.5-86.3），年龄> 50年（或7.2; 95％CI 2.8-18.5），局灶性弱点（或4.15; 95％CI 1.75-9.8）。其他变量降低了中风的机会：偏头痛历史（或0.05; 95％CI 0.01-0.4），癫痫（或0.13; 95％CI 0.02-0.8），痛苦（或0.1; 95％CI 0.04-0.3）和PrecordialGia（或0.045; 95％CI 0.002-0.9）。利用焦点弱点，计算机断层血管造影结果和前型痛苦的回归模型具有90.2％的预测精度。结论：IVF中风模仿的并发症率低。某些临床特征似乎预测卒中模拟，特别是正常计算断层血管造影。如果确认，这可能有助于防止没有中风的患者给予IVF。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号