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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Cerebral Microbleeds are Associated with Higher Mortality Among Ischemic Stroke Patients
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Cerebral Microbleeds are Associated with Higher Mortality Among Ischemic Stroke Patients

机译：脑微微肌肉与缺血性卒中患者的死亡率较高有关

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BackgroundSeveral studies have shown that cerebral microbleeds (CMBs) increase the risk of long-term stroke-related mortality. The purpose of this study was to determine if the existence and burden of CMBs are a predictor of in-hospital death among patients with acute ischemic stroke (AIS). MethodsWe studied consecutive ischemic stroke patients who admitted to our tertiary center over a 2-year period (2013-2014). Patients who underwent thrombolysis were excluded. Baseline characteristics of patients, number and topography of CMBs, white matter lesions, and spontaneous symptomatic hemorrhagic transformation were recorded. Outcome measure in our study was in-hospital death. ResultsOut of 1126 consecutive AIS patients evaluated in this study, 772 patients included in the study (mean age 61.9 ± 14.2years [18-95 years], 51.6% men, and 58.2% African American). CMBs were present on the magnetic resonance imaging (MRI) sequences of 124 (16.1%) patients. The overall rate of in-hospital mortality was 4.1%. The presence or absence of CMBs was not predictive of in-hospital mortality (P?=?.058). After adjusting for potential confounders, the presence of ≥4 CMBs on T2*-weighted MRI was independently (P?=?.004) associated with a higher likelihood of in-hospital death (odds ratio: 6.6, 95% confidential interval: 2.50 and 17.46) in multivariable logistic regression analyses. Older age, higher National Institute of Health stroke scale, and history of atrial fibrillation were also associated with greater chance of in-hospital death. ConclusionsThe presence or absence of CMBs was not predictive of in-hospital mortality. However, the presence of multiple CMBs was associated with a higher in-hospital mortality rate among AIS patients.
机译：背景鉴定表明，脑微杂种（CMBS）增加了长期行程相关死亡率的风险。本研究的目的是确定CMBS的存在和负担是否是急性缺血性卒中（AIS）患者中医院死亡的预测因子。方法网络与2年期间录取了我们的第三次中心的连续缺血性脑卒中患者（2013-2014）。不包括接受溶栓的患者。记录了CMBS，白质病变和自发症状出血性转化的患者基线特征，数量和地形。我们研究中的结果措施是医院死亡。在本研究中评估的1126名连续AIS患者的结果，772名患者包括在研究中（平均年龄为61.9±14.2年[18-95岁]，51.6％的男性和58.2％的非洲裔美国人）。在124（16.1％）患者的磁共振成像（MRI）序列上存在CMBS。住院内部死亡率的总体率为4.1％。 CMBS的存在或不存在于医院内死亡率（p？= 058）。调整潜在混凝剂后，T2 *重量的MRI上的≥4cmbs的存在独立（p？=Δ.004）与医院死亡的可能性更高（赔率比：6.6,95％的机密间隔：2.50 17.46）在多变量逻辑回归分析中。年龄较大的，高等国家健康冲程规模，和心房颤动的历史也与医院内死亡的更多机会有关。结论存在或不存在CMBS没有预测住院医生的死亡率。然而，多种CMBS的存在与AIS患者之间的较高的院内死亡率有关。

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