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The Significance of Contrast Density of the Computed Tomography-Angiographic Spot Sign and its Correlation with Hematoma Expansion

机译:计算机断层造影血管造影点标志对比度密度的重要性及其与血肿扩张的相关性

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Background and Purpose: The computed tomography angiographic (CTA) spot sign has been shown to predict hematoma expansion in patients with intracranial hemorrhage (ICH), but the significance of the spot sign density (SSD) and the spot sign ratio (SSR) has not yet been explored. Methods: Using the institutional Neurocritical care and Stroke registry, we retrospectively reviewed patients with ICH from January-2013 to June-2017. We selected patients who had baseline CT-head (CTH), CTA with positive-spot sign within 6 hours of last known well and at least one follow-up CTH within 24 hours. Baseline demographics and variables known to affect hematoma-volume were collected. Hematoma-volumes and SSR were calculated using computer-assisted 3D-volumetric measurement and the average of the surrounding hematoma density divided by the SSD, respectively. The 2-sample t test and the area-under-the-curve (receiver operating characteristic) were used to detect the association between hematoma expansion and outcome at discharge. Results: A total of 320 patients were reviewed; 22 met the inclusion criteria. Significant hematoma expansion (volume expansion >= 12.5 cc or >= 33% compared to baseline) was noted in 14 (64%) subjects. SSD was significantly higher in subjects with hematoma expansion (216 +/- 66) than those without (155 +/- 52, P=.036). With a cut-off SSD of >= 150 HU, we had sensitivity of 86% and specificity of 75%. For SSR, lower ratios suggested a trend toward hematoma expansion, although it was not statistically significant (P=.12). There was no significant correlation between SSD or SSR and modified ranking scale at discharge and after 3-6 months. Conclusion: SSD might be a good predictor of hematoma growth. Although SSR showed a trend toward expansion, results were not statistically significant.
机译:背景和目的:已显示计算机断层造影血管造影(CTA)斑点符号预测颅内出血(ICH)患者的血肿扩张,但斑点符号密度(SSD)和现场符号比(SSR)的意义没有还有探索。方法:采用机构神经科护理和中风登记,我们回顾性从2013年1月至2017年6月至2017年的ICH患者。我们选择患有基线CT-Head(CTH)的患者,CTA在上一次已知井的6小时内与阳性点签名,并且在24小时内至少进行一次随访的CTH。收集了已知影响血肿体积的基线人口统计和变量。使用计算机辅助的3D体积测量计算血肿 - 卷和SSR,分别计算出由SSD除以周围的血肿密度的平均值。使用2样品T测试和曲线(接收器操作特性)来检测血肿膨胀与出院的结果之间的关联。结果:综述了320名患者; 22符合纳入标准。 14(64%)受试者注意到,与基线相比,显着的血肿膨胀(体积膨胀> = 12.5cc或> = 33%)。 SSD在血肿膨胀(216 +/-66)的受试者中显着高于没有(155 +/- 52,P = .036)。随着SSD> = 150 Hu的截止,我们的敏感性为86%,特异性为75%。对于SSR,降低比率表明血肿扩张的趋势,尽管它没有统计学意义(p = .12)。 SSD或SSR之间没有显着的相关性,并在排出时和3-6个月后改性排名规模。结论:SSD可能是血肿生长的良好预测因子。虽然SSR表现出扩张的趋势,但结果没有统计学意义。

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