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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Novel Definition of Stroke 'Good Responders' Predicts 90-Day Outcome after Thrombolysis
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Novel Definition of Stroke 'Good Responders' Predicts 90-Day Outcome after Thrombolysis

机译：中风“好响应者”的小说定义预测溶栓后90天的结果

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Introduction: Identifying predictors of good response in thrombolytic-treated stroke is important to clinical care, resource allocation, and research design. We developed a simple, novel measure of "Good Responders" to assess if 2 short-term variables could predict 90-day outcomes after thrombolysis in stroke. Methods: Intravenous thrombolysis-treated stroke cases from June 2004 to June 2018 were analyzed from a stroke registry. Intraarterial treatment cases were excluded. Good responders (GR++) were defined as those with length of stay less than or equal to 3 days and discharge to home. Poor responders (GR- -) had length of stay more than 3 days and discharge other than home. Mixed responders (GR+/-) composed the remainder. Baseline characteristics and predictors of 90-day outcome were assessed. Results: Of 261 patients, there were 101(38.7%) GR++, 67(25.7%) GR- -, and 93(35.6%) GR+/-. For GR++ versus GR- - versus GR+/-, there were differences in mean age (62.7, 71.2, 69.2; P = .0016), and baseline modified Rankin score (mRS) 0-2 (%: 94.9, 74.6, 84.8; P = .008). Younger age, male sex, lower values for systolic BP, glucose, and baseline mRS were associated with good responders. Older age, atrial fibrillation, symptomatic intracerebral hemorrhage, and baseline mRS greater than 2 were associated with poor responders. At 90 days, mortality was reduced in GR++ versus GR- - versus GR+/- (%alive: 92.6, 72, 86; P = .04), and mRS(0-2) (%: 36.8, 0, 11.8; P < .001). Conclusions: Good responders to thrombolysis are younger and have better baseline functional status. Our novel definition of "Good Responders", using 2 early variables of home disposition and short length of stay, may help predict 90-day post-thrombolytic outcome. Future work should focus on validating this definition.
机译：简介：鉴定溶栓治疗中良好反应的预测因子对临床护理，资源分配和研究设计很重要。我们开发了一种简单的新颖衡量标准的“好响应者”，以评估2个短期变量是否可以在中风溶栓后预测90天的结果。方法：从冲程登记处分析2004年6月至2018年6月静脉溶栓治疗的中风病例。排除鼻内治疗病例。良好的响应者（GR ++）被定义为保持时间长度小于或等于3天和的房屋。糟糕的响应者（GR-）的逗留时间超过3天以上，除了家庭以外放电。混合响应者（GR +/-）组成了剩余的。评估了90天结果的基线特征和预测因子。结果：261例患者，有101例（38.7％）GR ++，67（25.7％）GR-，93（35.6％）GR +/-。对于GR ++与GR +/-，平均年龄的差异（62.7,71.2,69.2; p = .0016），以及基线改造的Rankin得分（MRS）0-2（％：94.9,74.6,84.8; p = .008）。年龄较小，男性性别，收缩性BP，葡萄糖和基线MRS的较低值与良好的响应者有关。年龄较大的年龄，心房颤动，症状性脑出血，大于2的基线MRS与贫困者有关。在90天时，GR ++与GR +/-（％活着：92.6,72,86; p = .04）和MRS（0-2）（％：36.8,0,11.8; p <.001）。结论：溶栓栓塞的好响应者是年轻的，并且具有更好的基线功能状态。我们的小说定义“良好的响应者”，使用2早期的家庭处置变量和短期的逗留时间，可能有助于预测90天后溶栓结果。未来的工作应该专注于验证这个定义。

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