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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Safety and Outcome of Endovascular Treatment for Minor Ischemic Stroke: Results From the Multicenter Clinical Registry of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands
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Safety and Outcome of Endovascular Treatment for Minor Ischemic Stroke: Results From the Multicenter Clinical Registry of Endovascular Treatment of Acute Ischemic Stroke in the Netherlands

机译：轻微缺血性卒中血管内治疗的安全性和结果：荷兰急性缺血性脑卒中血管内治疗多中心临床登记

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Goal: Insufficient data is available about safety and efficacy of endovascular treatment (EVT) in patients with minor stroke symptoms because these patients were excluded from most randomized trials. We aimed to compare characteristics, functional outcome, and complications in patients with minor ischemic stroke National Institutes of Health Stroke Scale score = 5 (NIHSS score = 5) and moderate to severe ischemic stroke (NIHSS score = 6) due to intracranial proximal artery occlusion of the anterior circulation who underwent EVT. Materials and Methods: We report patients with an anterior circulation occlusion who were included between March 2014 and June 2016 in the multicenter randomized clinical trial of EVT of acute ischemic stroke in the Netherlands Registry, a prospective, multicenter, observational study for stroke centers that perform EVT in the Netherlands. Minor ischemic stroke was defined as baseline NIHSS score of 5 or less. Primary outcome is the modified Rankin Scale (mRS) score at 90 days. Secondary outcomes include symptomatic intracranial hemorrhage (sICH) and mortality. Findings: Seventy-one (5.5%) patients had a NIHSS score of 5 or less. Functional independence (mRS 0-2 at 90 days) was reached in 75% of these patients, compared to 40% of patients with NIHSS score of 6 or more. sICH occurred in 4% of patients, of which 1% occurred peri-interventionally. Death occurred in 6% of patients. Conclusions: Patients with minor ischemic stroke with an intracranial proximal arterial occlusion of the anterior circulation who underwent EVT have a high chance of favorable outcome and appear to have low occurrence of treatment-related sICH. Therefore, our results encourage the use of EVT for minor ischemic stroke in the absence of effect estimates from controlled studies.
机译：目标：数据不足，腹血管治疗（EVT）对轻微中风症状患者的安全性和有效性，因为这些患者被排除在大多数随机试验中。我们的旨在比较患有轻微缺血性卒中国家健康卒中量表评分的患者的特征，功能结果和并发症，并且= 5（NIHSS得分= 5）和中度至严重缺血性卒中（NIHSS得分= 6）由于患有eVT的前循环的颅内近端动脉闭塞。材料和方法：我们向荷兰登记处的急性缺血性脑卒中evt的多中心随机临床试验中包括一项前循环闭塞患者，荷兰登记处的急性缺血性脑卒中的多中心随机临床试验，展望中心的前瞻性，多中心，观察学习在荷兰evt。轻微的缺血性卒中被定义为基线NIHSS得分为5或更小。主要结果是90天的改进的Rankin规模（MRS）得分。二次结果包括症状颅内出血（SICH）和死亡率。调查结果：七十一（5.5％）患者的NIHSS得分为5或更低。这些患者的75％达到了功能独立性（90天的MRS），而40％的NIHSS得分为6以上。 Sich发生在4％的患者中，其中1％发生了Peri-Sinutionally。死亡发生在6％的患者中。结论：患有轻微缺血性脑卒中的患者，颅内近端动脉闭塞，前血液循环均具有很大的有利结果的机会，并且似乎具有低发生的治疗相关的SICH。因此，我们的结果鼓励在没有受控研究的效果估计的情况下使用EVT进行轻微缺血性卒中。

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