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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Aerobic Training Efficacy in Inflammation, Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol
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Aerobic Training Efficacy in Inflammation, Neurotrophins, and Function in Chronic Stroke Persons: A Randomized Controlled Trial Protocol

机译：炎症，神经营养素和慢性卒中人员功能的有氧训练疗效：随机对照试验方案

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Background: Neuroinflammation is an important part of stroke pathophysiology and has both detrimental and beneficial effects after stroke. Besides that the enhancement of neurotrophins seems to be related to improvements in stroke recovery. Evidences suggest that exercise plays a role in modulating anti-inflammatory and neurotrophic effects. However, little is known about its impact in stroke survivors, mainly in chronic stroke. The purpose of this study is to investigate the efficacy of moderate-intensity treadmill exercise in changing inflammatory mediators, interleukin-6 (IL-6), soluble tumor necrosis factor receptors I and II (sTNFRI, sTNFRII), interleukin-10 (IL-10), and brain-derived neurotrophic factor (BDNF) levels in chronic stroke patients. The secondary objective is to investigate the effects of training in improve mobility and exercise capacity. Methods: This is a randomized controlled trial. Chronic stroke patients will be randomized to an experimental or control group, and will receive group interventions three times per week, over 12 weeks. The experimental group will receive moderate-intensity (60%-80% of maximum heart rate reserve) treadmill exercise. Control group will perform walking training on the ground (40% of maximum heart rate reserve). Primary outcomes include IL-6, sTNFRI, sTNFRII, IL-10, and BDNF levels. Secondary outcomes include mobility and exercise capacity. Outcomes will be measured at baseline, postintervention, and at the 4-week follow-up. Discussion: The findings of this trial have the potential to provide important insights regarding the effects of an aerobic physical program in the inflammatory process and in the neuronal plasticity in stroke persons and its impact on mobility and exercise capacity.
机译：背景：神经引征是中风病理学生理学的重要组成部分，卒中后既有有害和有益的效果。此外，神经营养素的增强似乎与中风恢复的改善有关。证据表明，运动在调节抗炎和神经营养效果方面发挥作用。然而，对于它在中风幸存者的影响几乎没有人熟知，主要是慢性中风。本研究的目的是探讨中等强度跑步机运动在改变炎症介质，白细胞介素-6（IL-6），可溶性肿瘤坏死因子受体I和II（STNFRI，STNFRII），白细胞介素-10（IL-）中的疗效10），慢性中风患者的脑源性神经营养因子（BDNF）水平。次要目标是调查培训改善流动性和运动能力的影响。方法：这是一个随机对照试验。慢性中风患者将被随机化为实验或对照组，并将每周三次接受群体干预措施，超过12周。实验组将获得中等强度（最大心率储量的60％-80％）跑步机运动。对照组将在地面上进行行走训练（最高40％的心率储备）。主要结果包括IL-6，STNFRI，STNFRII，IL-10和BDNF水平。二次结果包括流动性和运动能力。结果将在基线，初期，并在4周的后续行动中测量结果。讨论：该试验的调查结果有可能为有氧物理计划在炎症过程中的影响以及中风人中的神经元塑性的影响提供重要见解及其对流动性和运动能力的影响。

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