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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Three-Month Outcomes Are Poor in Stroke Patients with Cancer Despite Acute Stroke Treatment
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Three-Month Outcomes Are Poor in Stroke Patients with Cancer Despite Acute Stroke Treatment

机译：患有急性中风治疗的脑卒中患者的脑卒中患者的三个月结果

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Introduction: Stroke risk is increased in cancer patients. Prognosis in these patients is poor, with higher in-hospital mortality and increased subsequent mortality. However, data on stroke in cancer patients are limited, specifically regarding acute stroke treatment and functional outcomes. We aim to determine the functional outcomes of cancer patients admitted with acute stroke. Materials and Methods: We retrospectively reviewed patients carrying a diagnosis of cancer who were admitted with acute ischemic stroke between March 2013 and February 2016. Demographics, cerebrovascular risk factors, stroke characteristics including acute treatment, and characteristics of their cancer history and treatment were abstracted. The primary outcome measures included in-hospital mortality and 3-month functional outcome (as assessed by the modified Rankin Scale [mRS] score, with mRS scores of 3-6 considered poor functional outcome). Further outcome measures included length of stay and discharge destination. Findings: Forty-nine patients met the inclusion criteria, with a median admission National Institutes of Health Stroke Scale score of 8. Twelve patients (24.4%) underwent acute stroke treatment. The most common stroke etiology was hypercoagulability of malignancy (21, 42.9%). The three-month mortality was 46.9%; half of survivors had poor functional outcome. Functional outcomes did not differ by cancer type, stage, or year since diagnosis; on multivariate analysis only high admission NIHSS score was associated with poor functional outcome (P = .002). Conclusion: Nearly half of patients with cancer and stroke die within 3 months, and functional outcome is poor for 50% of 3-month survivors despite consideration of acute stroke treatment. Future research should address the role of hypercoagulability in the outcome prediction of stroke patients with cancer.
机译：介绍：癌症患者中风风险增加。这些患者的预后差，患有较高的内部死亡率和随后的死亡率增加。然而，癌症患者中风的数据是有限的，特别是关于急性中风治疗和功能性结果。我们的目标是确定癌症患者的功能结果，急性中风。材料与方法：我们回顾性地审查了患有2013年3月至2016年3月间在急性缺血性脑卒中的癌症诊断的患者。提高了人口统计，脑血管危险因素，包括急性治疗的中风特征，以及其癌症历史和治疗的特征。主要的结果措施包括医院死亡率和3个月的功能结果（由改进的Rankin Scale [Mrs]得分评估，3-6夫人认为功能结果不佳）。进一步的结果措施包括留下和排放目的地的长度。调查结果：四十九名患者达到了纳入标准，中位入院国立卫生卒中量表评分为8.十二名患者（24.4％）接受急性卒中治疗。最常见的卒中病因是恶性肿瘤的高凝（21,42.9％）。三个月的死亡率为46.9％;一半的幸存者功能结果差。癌症类型，阶段或年份以来的功能结果没有差异差异;在多变量分析上，只有高通量NIHSS得分与功能结果差有关（P = .002）。结论：近一半的癌症和中风死亡患者在3个月内死亡，尽管考虑了急性中风治疗，但3个月的幸存者的功能结果差。未来的研究应解决高凝患者在患有癌症患者的结果预测中的作用。

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