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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Impact of Multiple Chronic Conditions in Patients Hospitalized with Stroke and Transient Ischemic Attack
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Impact of Multiple Chronic Conditions in Patients Hospitalized with Stroke and Transient Ischemic Attack

机译：患有中风和短暂性缺血攻击患者患者的多重慢性病的影响

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Background: The prevalence and clinical impact of chronic conditions (CCs) have increasingly been recognized as an important public health concern. We evaluated the prevalence of coexisting CCs and their association with 30-day mortality and readmission in hospitalized patients with stroke and transient ischemic attack (TIA). Methods: In a retrospective study of patients aged >= 18 years hospitalized for first-ever stroke and TIA, we assessed the prevalence of coexisting CCs and their predictive value for subsequent 30-day mortality and readmission. Results: Study cohort comprised 6771 patients, hospitalized for stroke (n = 4068) and TIA (n = 2703), 51.4% men, with mean age of 68.2 years (standard deviation: +/- 15.6), mean number of CCs of 2.9 (+/- 1.7), 30-day mortality rate of 8.6% (entire cohort), and 30-day readmission rate of 9.7% (in 2498 patients limited to Olmsted and surrounding counties). In multivariable models, significant predictors of (1) 30-day mortality were coexisting heart failure (HF) (odds ratio [OR]: 1.45, 95% confidence interval [CI]: 1.09-1.92), cardiac arrhythmia (OR: 1.74, 95% CI: 1.40-2.17), coronary artery disease (CAD) (OR: 1.64, 95% CI: 1.29-2.08), cancer (OR: 1.67, 95% CI: 1.31-2.14), and diabetes (HR: 1.28, 95% CI: 1.01-1.62); and (2) 30-day readmission (n = 2498) were CAD (OR: 1.50, 95% CI: 1.09-2.07), cancer (OR: 1.46, 95% CI: 1.01-2.10), and arthritis (OR: 1.62, 95% CI: 1.09-2.40). Conclusions: In patients hospitalized with stroke and TIA, CCs are highly prevalent and influence 30-day mortality and readmission. Optimal therapeutic and lifestyle interventions for CAD, HF, cardiac arrhythmia, cancer, diabetes, and arthritis may improve early clinical outcome.
机译：背景：慢性病（CCS）的患病率和临床影响越来越被认为是一个重要的公共卫生问题。我们评估了共存CCS的患病率及其与30天死亡率和入院患者中风和短暂性缺血症患者（TIA）的入院患者的患病率。方法：在第一次中风和TIA住院治疗18岁的患者的回顾性研究中，我们评估了共存CCS的患病率及其在随后的30天死亡率和入院的预测价值。结果：研究队列组成6771名患者，住院中风（n = 4068）和TIA（n = 2703），男性为51.4％，平均年龄为68.2岁（标准差：+/- 15.6），平均CC的数量为2.9 （+/- 1.7），30天死亡率为8.6％（整个队列），30天登记率为9.7％（2498名患者限于OLMSTED及周边县）。在多变量模型中，（1）30天死亡率的显着预测因子共存心力衰竭（HF）（差距[或]：1.45,95％置信区间[CI]：1.09-1.92），心脏心律失常（或：1.74， 95％CI：1.40-2.17），冠状动脉疾病（CAD）（或：1.64,95％CI：1.29-2.08），癌症（或：1.67,95％CI：1.31-2.14）和糖尿病（HR：1.28 ，95％CI：1.01-1.62）; （2）30天的阅览（n = 2498）是CAD（或：1.50,95％CI：1.09-2.07），癌症（或：1.46,95％CI：1.01-2.10）和关节炎（或：1.62 ，95％CI：1.09-2.40）。结论：患有中风和TIA住院的患者，CCS高度普遍，影响了30天的死亡率和再入院。用于CAD，HF，心律失常，癌症，糖尿病和关节炎的最佳治疗和生活方式干预可能改善早期临床结果。

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