...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Sex-Related Differences in the Risk of Hospital-Acquired Sepsis and Pneumonia Post Acute Ischemic Stroke
【24h】

Sex-Related Differences in the Risk of Hospital-Acquired Sepsis and Pneumonia Post Acute Ischemic Stroke

机译：与医院败血症和肺炎后急性缺血性卒中风险的性与性差异

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and Objective: Infectious complications after ischemic stroke are frequent and lead to neurological deterioration, poor functional outcomes, and higher mortality. Local and systemic inflammatory responses to brain ischemia differ between males and females, but little is known about differences in poststroke susceptibility to infection by sex. The purpose of this study was to compare sex-related differences in the risk of hospital-acquired sepsis and pneumonia after acute ischemic stroke (AIS). Materials and Methods: This is a retrospective, secondary analysis of the 2010-2011 California State Inpatient Database. Previously validated International Classification of Disease, Ninth Revision (ICD-9) codes were used to identify adult hospitalizations for AIS. The primary outcome was hospital-acquired sepsis or pneumonia, also identified using ICD-9 codes. Associations between sex and hospital-acquired sepsis or pneumonia were adjusted for baseline characteristics and comorbidities using multivariable logistic regression. Results: There were 91,643 hospitalizations for AIS included in this analysis, of which 1027 had hospital-acquired sepsis and 1225 had hospital-acquired pneumonia. The in-hospital mortality without infection was 4.6%; the presence of hospital-acquired infections was associated with higher mortality for sepsis (32.7%) and pneumonia (21.9%). Female (versus male) sex was associated with lower adjusted odds of hospital-acquired sepsis (odds ratio [OR].74, 95% confidence interval [CI].65-.84) and pneumonia (OR.69, 95% CI.62-.78). This difference was similar across age strata. Among hospitalizations with either hospital-acquired sepsis or pneumonia, sex did not influence mortality. Conclusions: Female sex was associated with a lower risk of hospital-acquired sepsis and pneumonia after AIS. Further investigation is needed to determine the mechanisms underlying this clinical observation.
机译：背景和目的：缺血性卒中后的传染性并发​​症频繁，导致神经系统恶化，功能性差，较高的死亡率。对脑缺血的局部和全身炎症反应在雄性和女性之间不同，但对性别感染的失败易感性差异很少。本研究的目的是在急性缺血性卒中（AIS）后，比较医院收购败血症和肺炎风险的性与肺炎风险。材料和方法：这是2010-2011加利福尼亚州住院内部数据库的回顾性，二次分析。以前经过验证的国际疾病分类，第九次修订（ICD-9）代码用于识别AIS的成人住院治疗。主要结果是医院获得的败血症或肺炎，也使用ICD-9代码确定。使用多变量逻辑回归调整性和医院收购的败血症或肺炎的脓毒症或肺炎的关联。结果：在此分析中包含91,643名住院治疗AIS，其中1027名已有医院获得的败血症，1225名已有医院获得的肺炎。没有感染的住院死亡率为4.6％;医院获得的感染的存在与败血症（32.7％）和肺炎（21.9％）的较高死亡率有关。雌性（与男性）性别有关的情况与医院获得的败血症的调整率降低（差距[或] .74,95％置信区间[CI] .65-.84）和肺炎（或69,95％CI。 62-.78）。这种差异在患者中患者中的差异相似。在医院获得的败血症或肺炎的住院期间，性别不会影响死亡率。结论：在AIS后，女性性别与医院获得的脓毒症和肺炎的风险较低。需要进一步调查来确定该临床观察的基础。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号