...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >PR Interval Prolongation and Cryptogenic Stroke: A Multicenter Retrospective Study
【24h】

PR Interval Prolongation and Cryptogenic Stroke: A Multicenter Retrospective Study

机译：PR间隔延长和密码脑卒中：多中心回顾性研究

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background Atrial dysfunction or “cardiopathy” has been recently proposed as a mechanism in cryptogenic stroke. A prolonged PR interval may reflect impaired atrial conduction and thus may be a biomarker of atrial cardiopathy. We aim to compare the prevalence of PR interval prolongation in patients with cryptogenic stroke (CS) when compared with known non-cryptogenic non-cardioembolic stroke (NCNCS) subtypes. Methods We used prospective ischemic stroke databases of 3 comprehensive stroke centers to identify patients 18 years or older with a discharge diagnosis of ischemic non-cardioembolic stroke between December 1, 2013 and August 31, 2015. The main outcome was ischemic stroke subtype (CS versus NCNCS). We compared PR intervals as a continuous and categorical variable (200?milliseconds; ≥200?milliseconds) and other clinical and demographic factors between the 2 groups and used multivariate regression analyses to determine the association between PR interval prolongation and CS. Results We identified 644 patients with ischemic non-cardioembolic stroke (224 CS and 420 NCNCS). Patients with CS were more likely to have a PR of 200?milliseconds or greater when compared with those with NCNCS (23.2% versus 13.8%, P ?=?.009). After adjusting for factors that were significant in univariate analyses, a PR?of 200?milliseconds or greater was independently associated with CS (odds ratio [OR] 1.70, 95% CI 1.08-2.70). The association was more pronounced when excluding patients on atrioventricular nodal blocking agents (OR 2.64, 95% CI 1.44-4.83). Conclusions A PR of 200?milliseconds or greater is associated with CS and may be a biomarker of atrial cardiopathy in the absence of atrial fibrillation. Prospective studies are needed to confirm this association. ]]>
机译：最近提出了背景心房功能障碍或“心肌病”作为隐生脑卒中中的机制。延长的Pr间隔可能反映风雨壁传导受损，因此可能是心房心脏病的生物标志物。与已知的非密码源性非心脏栓塞中风（NCNC）亚型相比，我们的目标是比较患有隐源性中风（CS）患者的PR间隔延长的患病率。方法采用预期缺血卒中数据库3综合性卒中中心，鉴定18岁或以上的患者，2013年12月1日至2015年8月31日之间的缺血非心电图中风放电诊断。主要结果是缺血性卒中亚型（CS与NCNC）。我们将PR间隔与2组之间的连续和分类变量进行比较为连续和分类变量（＆ 200？毫秒）和其他临床和人口因子和使用多元回归分析，以确定Pr间隔延长和Cs之间的关联。结果我们鉴定了644例缺血性非心脏栓塞中风（224℃和420个NCNC）的患者。与NCNC的人相比，CS患者更容易有200毫秒或更大的PR（23.2％对13.8％，P？= 009）。调整单变量分析中显着的因素后，PR-200？毫秒或更大独立与Cs（赔率比[或] 1.70,95％CI 1.08-2.70）相关。在排除房室结节封闭剂（或2.64,95％CI 1.44-4.83）上排除患者时，该协会更加明显。结论200？毫秒或更大的PR与Cs相关，并且可能是在没有心房颤动的情况下是心房心脏病的生物标志物。需要预期研究来确认这一协会。 ]]>

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号