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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack
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High On-Treatment Platelet Reactivity to Adenosine Diphosphate Predicts Ischemic Events of Minor Stroke and Transient Ischemic Attack

机译：对腺苷二磷酸的高处理血小板反应性预测轻微中风和短暂性缺血发作的缺血事件

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Background This study aimed to evaluate the relationship between thromboelastography adenosine diphosphate maximum amplitude (TEG-ADP MA ) and recurrent ischemic events in patients with minor ischemic stroke or high-risk transient ischemic attack (TIA). Methods A total of 265 patients received dual antiplatelet therapy were consecutively enrolled. High on-treatment platelet reactivity (HTPR) to ADP was assessed by TEG-ADP MA and detected the CYP2C19 genotype; recurrent ischemic events were followed up for 90 days after onset. The difference of recurrent ischemic events was analyzed with or without HTPR to ADP by the Kaplan–Meier, and further to determine the difference of recurrent ischemic events in each group according to TEG-ADP MA -based tertile distribution. Results A total of 23 (8.6%) patients had recurrent ischemic events. TEG-ADP MA greater than or equal to 48?mm had good predictive value. Whether these patients were divided into 2 groups or 3 groups, the HTPR to ADP group had higher risk of recurrent ischemic events than the normal on-treatment platelet reactivity to ADP group by the Kaplan–Meier (all, P ??.05). The tertile distribution map showed that the results of recurrent ischemic events were statistically significant in the third tertile group compared with the other two groups (all, P ??.03); also, the third tertile group had a higher rate of carriers of at least 1 CYP2C19 reduced-function allele than the other two groups ( P ??.05). Conclusions In patients with minor ischemic stroke and high-risk TIA, the TEG-ADP MA could predict recurrent ischemic events and has auxiliary effect on clinical decision-making. ]]>
机译：背景技术本研究旨在评估血液血液腺苷二磷酸二磷酸二磷酸二磷酸二磷酸二磷酸二磷酸二磷酸二磷酸二磷酸二磷酸酯和经常性缺血事件的关系，患有轻微缺血性卒中或高危短期缺血性发作（TIA）的患者。方法共纳入265名患者接受双抗血小板治疗。通过TEG-ADP MA评估高处理血小板反应性（HTPR）至ADP，检测到CYP2C19基因型;经常性缺血事件发生在发病后90天。通过Kaplan-Meier分析复发性缺血事件的差异，并通过Kaplan-Meier进行ADP，并进一步根据TEG-ADP MA基于Tertifle分布确定每组复发性缺血事件的差异。结果共有23例（8.6％）患者具有复发性缺血事件。 TEG-ADP MA大于或等于48Ωmm具有良好的预测值。这些患者是否分为2组或3组，HTPR至ADP组的经常性缺血事件的风险较高，比Kaplan-Meier（全部，Pαα.05 ）。 Tertile分布图表明，与其他两组（全部，p≤0.03）相比，第三型型缺血事件的复发性缺血事件的结果在第三阶段统计学意义。此外，第三三型型载体的载体率高于除其他两组（P≤0.05）的载体的载体率高。结论患有轻微缺血性卒中和高风险TIA的患者，TEG-ADP MA可以预测复发性缺血事件，并对临床决策具有辅助效应。 ]]>

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