...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke
【24h】

Elevated Serum High-Mobility Group Box-1 Protein Level Is Associated with Poor Functional Outcome in Ischemic Stroke

机译：升高的血清高迁移率组箱-1蛋白质水平与缺血性卒中的功能性差异差有关

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background In experimental models, inhibition of high-mobility group box-1 (HMGB1) signaling has been reported to protect against the sequelae of ischemic stroke. Here, we determined the clinical significance of serum HMGB1 levels in patients with acute ischemic stroke. Methods We enrolled 183 patients (114 men, 69 women; mean age: 72.7 years) over 6 consecutive months. On admission and day 7, we recorded the National Institutes of Health Stroke Scale scores and measured serum high-sensitivity C-reactive protein (hs-CRP) and HMGB1 levels. Stroke volumes were estimated using diffusion-weighted magnetic resonance imaging performed on admission. One year later, clinical outcome was assessed using the modified Rankin Scale (mRS). Results Serum hs-CRP and HMGB1 levels in patients with ischemic stroke were increased relative to healthy controls (both P ??.01). On day 7, hs-CRP, but not HMBG1, levels had increased significantly relative to levels at admission ( P ??.01 and .54, respectively). Higher HMGB1, but not hs-CRP, levels at day 7 correlated with larger stroke volumes ( P ??.01 and .28, respectively). HMGB1 levels did not significantly differ between stroke subtypes. Multiple logistic regression analysis indicated that a serum HMGB1 level higher than 7.5?ng/mL was an independent risk factor for poor prognosis, defined as a 1-year mRS score of 3-6 (odds ratio, 2.34; 95% confidence interval, 1.02-5.38). Conclusions Acute ischemic stroke is associated with elevated serum HMGB1 levels, and HMGB1 levels at admission independently predict poor outcome at 1 year. These results suggest that HMGB1 quantification provides more accurate prognostic information after ischemic stroke. ]]>
机译：背景技术在实验模型中，据报道，抑制高迁移率组箱-1（HMGB1）信号传导以防止缺血性卒中后遗症。在这里，我们确定急性缺血性卒中患者血清HMGB1水平的临床意义。方法我们注册了183名患者（114名男子，69名女性;意思是年龄：72.7岁）连续6个月。在入学和第7天，我们记录了国家卫生卒中量表评分，并测量了血清高敏感性C-反应蛋白（HMGB1水平。利用在入院中进行的扩散加权磁共振成像估计行程量。一年后，使用改进的Rankin规模（MRS）评估临床结果。结果缺血性卒中患者的血清HS-CRP和HMGB1水平相对于健康对照（β1）相对于健康对照增加而增加。在第7天，HS-CRP，但不是HMBG1，水平相对于进入的水平显着增加（P？＆Δ.01和.54）。较高的HMGB1，但不是HS-CRP，第7天的水平与较大的中风体积相关（分别为01.01和.28）。中风亚型之间的HMGB1水平没有显着差异。多元逻辑回归分析表明，高于7.5的血清HMGB1水平是预后差的独立危险因素，定义为3-6的1年SA得分（赔率比，2.34; 95％置信区间，1.02 -5.38）。结论急性缺血性卒中与血清HMGB1水平升高有关，入院的HMGB1水平独立预测1年的差。这些结果表明HMGB1定量在缺血性卒中后提供更准确的预后信息。 ]]>

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号