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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >MMP Gene Polymorphisms, MMP-1-1607 1G/2G,-519 A/G, and MMP-12-82 A/G, and Ischemic Stroke: A Meta-Analysis
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MMP Gene Polymorphisms, MMP-1-1607 1G/2G,-519 A/G, and MMP-12-82 A/G, and Ischemic Stroke: A Meta-Analysis

机译：MMP基因多态性，MMP-1-1607 1G / 2G，-519 A / G和MMP-12-82 A / G，缺血性卒中：荟萃分析

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Background: Several polymorphisms in the human gene encoding MMP have been investigated for the association with ischemic stroke (IS) in the population, of which the MMP-1 -1607 1G/2G, -519 A/G, and MMP-12 -82 A/G polymorphisms gain more and more attention; however, the results are controversial and ambiguous. We therefore carried out the meta-analysis to yield a valid conclusion. Methods: The literature database was comprehensively searched to identify potentially eligible reports. Results: A total of 15 studies with 3237 cases and 3075 controls were included in this meta-analysis. Conclusions: There was a significant association in MMP-1 -1607 1C/2C and MMP-12 -82 A/G gene polymorphisms, but none was observed in MMP-1 -519 A/G. When a subgroup analysis by ethnicity and HWE, MMP-12 -82 A/G gene polymorphisms may be a risk factor for IS in Europe. In Africa, MMP-1 -16071G/2G and MMP-12 -82 A/G also showed a significant effect on IS. Further investigation on a larger sample size of different ethnic populations is needed to confirm the findings.
机译：背景：已经研究了编码MMP的人类基因中的几种多态性，用于与缺血性卒中（IS）的关联，其中MMP-1 -1607 1G / 2G，-519A / g和MMP-12 -82 a / g多态性增加了越来越多的关注;但是，结果是有争议的和暧昧的。因此，我们进行了META分析，以产生有效的结论。方法：全面搜索文献数据库，以确定可能符合条件的报告。结果：该荟萃分析中共有15项患有3237例和3075种对照的研究。结论：MMP-1 -1607 1C / 2C和MMP-12 -82 A / G基因多态性中存在显着关联，但在MMP-1 -519A / g中没有观察到。当通过种族和HWE的亚组分析，MMP-12 -82 A / G基因多态性可能是欧洲的危险因素。在非洲，MMP-1 -16071G / 2G和MMP-12 -82 A / G也显示出显着的影响。需要进一步调查不同种族种群的更大样本量来证实调查结果。

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