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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >24-Hour Alberta Stroke Program Early CT Score Assessment in Post-Stroke Spasticity Development in Patients with a First Documented Anterior Circulation Ischemic Stroke
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24-Hour Alberta Stroke Program Early CT Score Assessment in Post-Stroke Spasticity Development in Patients with a First Documented Anterior Circulation Ischemic Stroke

机译：24小时艾伯塔省中风计划早期CT评估患者中风后痉挛发育的评估，患有第一个文件前循环缺血性卒中的患者

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Background: Neuroanatomic substrates responsible for development of post-stroke spasticity are still poorly understood. The study is focused on identification of brain regions within the territory of the middle cerebral artery associated with spasticity development. Methods: This is a single-center prospective cohort study of first documented anterior circulation ischemic strokes with a neurologic deficit lasting 7 days (from March 2014 to September 2016, all patients are involved in a registry). Ischemic cerebral lesions within the territory of middle cerebral artery were evaluated using the Alberta Stroke Program Early CT Score (ASPECTS) on control 24-hour computed tomography or magnetic resonance imaging. Spasticity was assessed with modified Ashworth scale. Results: Seventy-six patients (mean age 72 years, 45% females; 30% treated with IV tissue plasminogen activator, 6.5% mechanical thrombectomy) fulfilled the study inclusion criteria. Forty-nine (64%) developed early elbow or wrist flexor spasticity defined as modified Ashworth scale 1 (at day 7-10), in 44 (58%) the spasticity remained present at 6 months. There were no differences between the patients who developed spasticity and those who did not when comparing admission stroke severity (National Institutes of Health Stroke Scale 5 [interquartile range {IQR} 4-8] versus 6 [IQR 4-10]) and vascular risk factors (hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, coronary artery disease). Nor was there a difference in 24-hour ASPECTS score (9 DQR 8-10] versus 9 DQR 7-10]). No differences were found between the groups with and without the early upper limb flexor spasticity of particular regions (M1, M2, M3, M4, M5, M6, lentiform, insula, caudate, intemal capsule) and pecentral-postcentral gyrus, premotor cortex, supplementary motor area, posterior limb of internal capsule, and thalamus were compared. Conclusions: We did not find any middle cerebral artery territory associated with post-stroke spasticity development by detailed evaluation of ASPECTS.
机译：背景技术：负责卒中后痉挛的发育的神经杀菌底物仍然很差。该研究专注于识别与痉挛发育相关的中脑动脉境内的脑区。方法：这是一个单中心预期队列研究，对首次记录的前循环缺血性缺血性血糖中风，具有神经系统缺陷持久性＆GT; 7天（从2014年3月至2016年9月，所有患者均参与登记处）。使用Alberta Stroke程序早期CT评分（方面）在控制24小时计算机断层扫描或磁共振成像中评估中脑动脉域内的缺血性脑病变。通过改进的Ashworth规模评估了痉挛。结果：七十六名患者（平均72岁，45％女性; 30％用IV组织纤溶酶原激活剂，6.5％机械血栓切除术）实现了研究纳入标准。第四十九（64％）发育的早期弯头或手腕屈肌痉挛定义为改进的Ashworth Scale＆Gt; 1（在第7-10天），44（58％）痉挛仍存在于6个月。发展痉挛的患者没有差异，并且在比较入院冲程严重程度时没有那些没有那些没有患者（国家卫生卒中规模5 [四分位数范围{IQR} 4-8]与6 [IQR 4-10]）和血管风险因子（高血压，糖尿病，血液化血症，心房颤动，冠状动脉疾病）。 24小时方面的分数（9 dqr 8-10]与9 dqr 7-10]）也没有差异。在具有和没有特定区域的早期上肢屈肌痉挛（M1，M2，M3，M4，M5，M6，乳胶，insula，尾状片，PeCentral-Postcenth Gyrus，Premotor Cortex，比较了辅助电机区域，内部胶囊的后肢和丘脑。结论：通过详细评估方面，我们没有发现与行程后痉挛发展相关的中脑动脉区域。

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