...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage
【24h】

Association of IL6ST (gp130) Polymorphism with Functional Outcome Following Spontaneous Intracerebral Hemorrhage

机译：IL6ST（GP130）多态性与自发脑出血后功能结果的关联

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and Purpose: Genes associated with the inflammatory response and cytostructural integrity may influence recovery following a brain injury. To examine this in the setting of spontaneous intracerebral hemorrhage (ICH), selected single nucleotide polymorphisms (SNPs) were assessed for associations with patient outcome. Methods: A cohort of 54 patients with supratentorial ICH were enrolled. Based on known involvement with neuroinflammation and cytostructural integrity, 10 preselected SNPs from 6 candidate genes were tested for associations with 6-month functional outcome (modified Rankin Scale [mRS] = 3), mortality, and in-hospital deterioration (Glasgow Coma Scale decrease by 2 within 7 days of admission) following ICH. Fisher's exact test and logistic regression with adjustment for race and ICH score were performed. Results: SNP rs10940495 (gp130 G/A) within the gp130 gene was the only SNP significantly associated with lower odds of an unfavorable 6-month functional outcome (odds ratio = .16 for mRS = 3; 95% confidence interval,.03-.87, P =.03). Compared with major allele (A) homozygotes, minor allele (G) carriers in the IL6 signal transducer gene (gp130) locus were 84% less likely to have a poor outcome (mRS = 3) at 6 months following spontaneous ICH. The SNP rs10940495 (gp130 G/A) and SNP rs3219119 (PARP-1 A/T) were associated with 6-month mortality (P = .02 and .04, respectively) only on univariate analysis. None of the SNPs examined were associated with in-hospital deterioration. Conclusion: In this exploratory study, SNP rs10940495 in the gp130 locus was associated with functional outcome at 6 months following spontaneous ICH. These findings, which should be validated through a larger study, suggest that inflammation plays an important role in mediating outcomes after ICH.
机译：背景和目的：与炎症反应和细胞结构完整相关的基因可能在脑损伤后影响恢复。为了在自发脑出血（ICH）的设定中来检查这一点，评估选定的单核苷酸多态性（SNP）与患者结果的关联。方法：注册了54例Supratental Ich患者的群组。基于已知的患有神经炎炎症和细胞结构完整性的参与，测试了来自6个候选基因的预选的SNP，用于6个月的功能结果（改进的Rankin Scale [Mrs] = 3），死亡率和院内康复（Glasgow Coma）在入院后7天内的缩放减少）在ICH之后。进行Fisher对种族和ICH评分进行调整的确切测试和逻辑回归。结果：GP130基因内的SNP RS10940495（GP130 G / A）是唯一与不利的6个月功能结果的少数显着相关的SNP（MRS＆GT的赔率比率= .16; = 3; 95％的置信区间，。 03-.87，p = .03）。与主要等位基因（A）纯合子相比，IL6信号传感器基因（GP130）轨迹中的次要等位基因（G）载体在自发ICH后6个月在6个月内具有较差的结果（MRS＆GT. = 3）的可能性较差84％。 SNP RS10940495（GP130 G / A）和SNP RS3219119（PARP-1 A / T）只与单变量分析仅在6个月死亡率（P = .02和.04）相关。检查的SNP没有与住院内的恶化有关。结论：在该探索性研究中，GP130基因座中的SNP RS10940495与自发ICH后6个月的功能结果相关。这些发现应该通过较大的研究验证，表明炎症在ICH之后介导的结果发挥着重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号