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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Sex Differences in Outcomes after Stroke in Patients with Diabetes in Ontario, Canada
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Sex Differences in Outcomes after Stroke in Patients with Diabetes in Ontario, Canada

机译：加拿大安大略省糖尿病患者中风后的性差异

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Background: Outcomes after stroke in those with diabetes are not well characterized, especially by sex and age. We sought to calculate the sex- and age-specific risk of cardiovascular outcomes after ischemic stroke among those with diabetes. Methods: Using population-based demographic and administrative health-care databases in Ontario, Canada, all patients with diabetes hospitalized with index ischemic stroke between April 1, 2002, and March 31, 2012, were followed for death, stroke, and myocardial infarction (MI). The Kaplan-Meier survival analysis and Fine-Gray competing risk models estimated hazards of outcomes by sex and age, unadjusted and adjusted for demographics and vascular risk factors. Results: Among 25,495 diabetic patients with index ischemic stroke, the incidence of death was higher in women than in men (14.08 per 100 person-years [95% confidence interval [CI], 13.73-14.44] versus 11.89 [11.60-12.19]) but was lower after adjustment for age and other risk factors (adjusted hazard ratio [HR], .95 [.92-.99]). Recurrent stroke incidence was similar by sex, but men were more likely to be readmitted for MI (1.99 per 100 person-years [1.89-2.10] versus 1.58 [1.49-1.68] among females). In multivariable models, females had a lower risk of readmission for any event (HR, .96 [95% CI,.93-.99]). Conclusions: In this large, population-based, retrospective study among diabetic patients with index stroke, women had a higher unadjusted death rate but lower unadjusted incidence of MI. In adjusted models, females had a lower death rate compared with males, although the increased risk of MI among males persisted. These findings confirm and quantify sex differences in outcomes after stroke in patients with diabetes.
机译：背景：患有糖尿病的脑卒中后的结果并不具备很好的表征，尤其是性和年龄。我们试图在患有糖尿病患者中缺血性中风后的心血管结果的性别和年龄特异性风险。方法：采用加拿大安大略省的基于人口的人口和行政医疗数据库，2002年4月1日至2012年4月1日至2012年3月31日，患有指数缺血性脑卒中的糖尿病患者，均持续死亡，中风和心肌梗死（ MI）。 Kaplan-Meier生存分析和细灰色竞争风险模型通过性和年龄，不调整和调整人口统计和血管危险因素的估计对结果的危害。结果：25,495名患有指数缺血性卒中的糖尿病患者中，女性死亡发生率高于男性（每100人14.08人[95％置信区间[CI]，13.73-14.44]与11.89 [11.60-12.19]）但调整年龄和其他危险因素后较低（调整后危险比[HR]，.95 [.92-.99]）。经常性卒中发病率是相似的，但男性更有可能预约MI（每100人为1.99人 - 年[1.89-2.10]，女性中的1.58 [1.49-1.68]）。在多变量的型号中，雌性对任何事件的入伍风险较低（HR，.96 [95％CI，.93-.99]）。结论：在这种大型人口的糖尿病患者中，糖尿病患者的回顾性研究，女性未经调整的死亡率较高，但不调整的MI发病率降低。在调整后的模型中，与男性相比，女性的死亡率较低，尽管雄性中MI的风险增加持续存在。这些发现在糖尿病患者卒中后确认并量化了性差异。

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