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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Basilar Artery Dolichoectasia: Prevalence and Correlates With Markers of Cerebral Small Vessel Disease in Community-Dwelling Older Adults
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Basilar Artery Dolichoectasia: Prevalence and Correlates With Markers of Cerebral Small Vessel Disease in Community-Dwelling Older Adults

机译：基础动脉培养基型：患病率和与社区住宅年龄较大的成年人中脑小血管病标记相关

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Background: Basilar artery (BA) dolichoectasia has been associated with cerebral small vessel disease (SVD). However, studies have focused on stroke patients, and results cannot be extrapolated to the population at large. In this study, we aimed to assess prevalence of BA dolichoectasia and its association with SVD in communitydwelling older adults living in rural Ecuador. Methods: Atahualpa residents aged >= 60 years underwent brain magnetic resonance imaging and magnetic resonance angiography of intracranial vessels. Following Smoker's criteria, the mean BA diameter plus 2 standard deviation defined ectasia. In addition, a location lateral to the lateral margin of the clivus of dorsum sellae or a bifurcation at the third ventricle floor or higher defined dolichosis. Associations between BA abnormalities and imaging markers of SVD were assessed by the use of regression models adjusted for demographics and cardiovascular risk factors. Results: Of 346 participants, 11 (3.2%) had ectasia, 40 (11.6%) had dolichosis, and 47 (13.6%) had dolichoectasia (ectasia, dolichosis, or both). BA diameter was only associated with severity of white matter hyperintensities (P =.038). Dolichosis was associated with deep cerebral microbleeds (P =.002) but not with white matter hyperintensities. Dolichoectasia was associated with both white matter hyperintensities (P =.031) and cerebral microbleeds (P =.001). There were no associations with lacunar infarcts or enlarged perivascular spaces in any model. Conclusions: Prevalence of BA dolichoectasia in this rural setting is similar to that reported in other populations. Associations with imaging markers of SVD differ according to whether the subject has ectasia or dolichosis.
机译：背景：基底动脉（BA）Dolichoectasia与脑小血管疾病（SVD）有关。然而，研究专注于中风患者，结果不能在大的人群中推断出来。在这项研究中，我们旨在评估Ba Dolichoectasia的患病率及其与厄瓜多尔农村农村乡村成年人的SVD联系。方法：Atahualpa居民年龄> = 60年的颅内血管脑磁共振成像和磁共振血管造影。在吸烟者的标准之后，平均B​​A直径加2标准偏差定义的ectasia。另外，横向于背部溶藻的横向边缘或第三脑室地板或更高限定的偶氮含量的分叉横向横向。通过使用用于人口统计数据和心血管危险因素的回归模型来评估SVD的BA异常和成像标记之间的关联。结果：346名参与者，11名（3.2％）具有异亚肌，40个（11.6％）的卵黄素，47例（13.6％）具有DolichoectaSia（Ectasia，Dolichosis或两者）。 Ba直径仅与白质超收缩的严重程度相关（P = .038）。白细胞增分与深脑显微型（P = .002）相关，但不具有白质超萎缩性。白细胞增分与白质高萎缩性（P = .031）和脑微比物（P = .001）有关。在任何模型中没有与Levunar Infarcts或扩大的大脑空间有关。结论：这种农村环境中BA Dolichoectasia的患病率类似于其他人口报告的患者。根据受试者是否具有异亚肌肤或甘露胶质，具有SVD的成像标记的关联。

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