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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Time Course of Flow-Mediated Dilation and Vascular Endothelial Growth Factor following Acute Stroke
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Time Course of Flow-Mediated Dilation and Vascular Endothelial Growth Factor following Acute Stroke

机译：急性中风后流动介导的扩张和血管内皮生长因子的时间过程

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Objectives: People after stroke demonstrate alterations in vascular endothelial function measured by flow-mediated dilation. Limited information is available in the literature on possible protective factors following stroke. The aims of the secondary analysis were (1) to characterize the time course of vascular endothelial function using flow-mediated dilation at 72 hours after stroke and 1 week later during inpatient stroke rehabilitation and (2) to determine whether flow-mediated dilation was related to vascular endothelial growth factor, brain-derived neurotrophic factor, or estimated prestroke peak oxygen uptake. Methods: Flow-mediated dilation using Doppler ultrasound was assessed in bilateral brachial arteries at the defined time points. Flow-mediated dilation and blood draws occurred on the same day between 7: 30 AM and 9: 00 AM following an overnight fast. Enzyme-linked immunosorbent assay was used to quantify plasma vascular endothelial growth factor and brain-derived neurotrophic factor values. A nonexercise estimate was used to calculate prestroke peak oxygen uptake. Results: We have shown that between-limb differences are evident within 72 hours after stroke and remain 1 week later during inpatient rehabilitation. Higher values for vascular endothelial growth factor were associated with increased flow-mediated dilation at both time points. Higher estimated prestroke peak oxygen uptake was related to flow-mediated dilation. Brain-derived neurotrophic factor was not related to any outcome measures. Conclusions: Unique vascular adaptations start early after stroke in the stroke-affected limb and remain through inpatient stroke rehabilitation. Vascular endothelial growth factor and prestroke physical activity may have a protective role in vascular function following stroke. Future work should focus on mechanistic pathways for preservation of vascular health.
机译：目的：中风后的人现表通过流动介导的扩张测量的血管内皮函数的改变。文献中有限的信息可以在卒中后可能的保护区因子提供。二次分析的目的是（1），以在入口卒中康复后72小时后使用流量介导的扩张，在30小时后，在入住卒中康复期间和（2）期间，以确定流动介导的扩张是否有关对血管内皮生长因子，脑衍生的神经营养因子，或估计的PRESTROKE PEAT氧气吸收。方法：在定义的时间点的双侧肱动脉中评估使用多普勒超声的流动介导的扩张。流动介导的扩张和血液吸血在同一天发生在7:30和9:00之间发生过夜。酶联免疫吸附测定用于量化血浆血管内皮生长因子和脑衍生的神经营养因子值。非向估计数用于计算Prestroke峰值氧气吸收。结果：我们已经表明，在中风后72小时内，肢体差异是显而易见的，在住院康复期间仍然保持1周。血管内皮生长因子的较高值与两个时间点的流动介导的扩张增加相关。估计的Prestroke峰值氧气摄取与流动介导的扩张有关。脑衍生的神经营养因子与任何结果措施无关。结论：在中风影响的肢体中卒中早期开始独特的血管适应，并留在住院呼吸康复。血管内皮生长因子和普雷斯罗克身体活性可能在中风后血管功能中具有保护作用。未来的工作应专注于机械途径，以保存血管健康。

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