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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Patients with Cerebral Stroke Have an Increased Risk of Gastroesophageal Reflux Disease: A Population-Based Cohort Study
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Patients with Cerebral Stroke Have an Increased Risk of Gastroesophageal Reflux Disease: A Population-Based Cohort Study

机译：脑卒中患者具有增加的胃食管反流疾病风险：基于人群的队列研究

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Background: Medical complications following stroke often result in significant morbidity. This study was designed to investigate the prevalence and risk of gastroesophageal reflux disease (GERD) between patients with stroke and those without stroke in Taiwan. Methods and Results: This retrospective cohort study was conducted using the Taiwan National Health Insurance Research Database. The study included 18,412 patients newly diagnosed as having stroke during 2000-2006 and 18,412 patients without stroke frequency-matched by sex, age, and index year. All patients were followed from the index date to December 31, 2011. The Cox proportional hazards regression model was used to estimate the GERD risk. The GERD risk was approximately 1.51-times higher in the stroke group than in the nonstroke group, after adjustment for age, sex, and the cumulative incidence of some comorbidities. GERD was positively associated with stroke; the male sex (adjusted hazard ratio [HR] = 1.31); an age of 65 years or older (adjusted HR = 1.11); hyperlipidemia (adjusted HR = 1.14); ischemic heart disease (adjusted HR = 1.27); renal disease (adjusted HR = 1.45); and use of aspirin (adjusted HR = 2.34), clopidogrel (adjusted HR = 1.41), and dipyridamole (adjusted HR = 1.30). Conclusions: This study indicates a significantly higher GERD risk in patients with stroke than in the nonstroke group. In clinical practice, neurologists should focus on the risk of GERD symptoms. (c) 2018 National Stroke Association. Published by Elsevier Inc. All rights reserved.
机译：背景：中风后的医疗并发症通常会导致显着的发病率。本研究旨在探讨患有卒中患者与台湾中风的患者胃食管反流疾病（GERD）的患病率和风险。方法和结果：该回顾性队列研究是使用台湾国家健康保险研究数据库进行的。该研究包括在2000-2006和18,412名没有中风频率匹配的2000-2006和18,412名患者中患有18,412名患者。所有患者均遵循指数日期至2011年12月31日。Cox比例危害回归模型用于估计GERD风险。在调整年龄，性别和某些合并症的累积发病率之后，脑卒中群体的疾病风险比非行程组高约1.5.1倍。 GERD与中风有关;男性（调整后危险比[HR] = 1.31）;年龄65岁或以上（调整后的HR = 1.11）;高脂血症（调整HR = 1.14）;缺血性心脏病（调整后HR = 1.27）;肾病（调整后HR = 1.45）;并使用阿司匹林（调节的HR = 2.34），氯吡格雷（调节的HR = 1.41）和双嘧达莫（调节的HR = 1.30）。结论：本研究表明卒中患者的大幅度较高的疾病风险比非行程组在非行程中。在临床实践中，神经泌素应该关注GERD症状的风险。 （c）2018国家冲程协会。由elsevier Inc.保留所有权利发布。

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