首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >A Simple Geometric Assessment of Perfusion Lesion Volume at Hyperacute Stage of Ischemic Stroke in Patients with Symptomatic Steno-Occlusion of Major Cerebral Arteries and Risk of Subsequent Cerebral Ischemic Events
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A Simple Geometric Assessment of Perfusion Lesion Volume at Hyperacute Stage of Ischemic Stroke in Patients with Symptomatic Steno-Occlusion of Major Cerebral Arteries and Risk of Subsequent Cerebral Ischemic Events

机译:缺血性脑卒中患者缺血性脑卒中患者缺血性脑卒中患者的简单几何评价,以及随后的脑缺血事件风险

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摘要

Our objective is to elucidate the association of baseline perfusion lesion volume on perfusion-weighted magnetic resonance imaging (PWI) obtained at hyperacute stage of ischemic stroke with subsequent cerebral ischemic events (SIEs) in patients with symptomatic steno-occlusion of major cerebral arteries. Using a prospective stroke registry database, patients arriving within 24 hours of onset with symptomatic steno-occlusion of major supratentorial cerebral arteries were identified. On baseline PWI, time-to-peak lesion volume (TTP-LV) was determined by a simple geometric method and dichotomized into the highest tertile (large) and the other tertiles (small to medium) according to the vascular territory of occluded arteries. Primary outcome was a time to SIE up to 1 year after stroke onset. A total of 385 patients (a median time delay from onset to arrival, 2.2 hours) were enrolled. During the first year of stroke, the SIE rate of the large TTP-LV group was twice that of the small-to-medium TTP-LV group (35.7% versus 17.4%; P < .001). Large TTP-LV independently raised the hazard of SIE (hazard ratio, 2.24; 95% confidence interval, 1.45-3.44). This study demonstrates that TTP-LV on PWI measured through a simple geometric method at an emergency setting can be used to predict progression or recurrence of ischemic stroke in patients with symptomatic steno-occlusion of major cerebral arteries.
机译:我们的目的是阐明基线灌注病变体积对在缺血性脑卒中的超急性阶段获得的灌注加权磁共振成像(PWI)的关联,其随后脑缺血事件(SIES)患有主要脑动脉的症状闭塞患者。使用潜在中风注册表数据库,确定了患者在24小时内抵达的患者与主要的SuprateLeral脑动脉的症状闭塞发生。在基线PWI上,通过简单的几何方法测定时间 - 峰值病变体积(TTP-LV),并根据闭塞动脉的血管域分解成最高的Tertile(大)和其他截头(小至中等)。初级结果是在中风发作后长达1年的时间。共有385名患者(起始到达的中位时间延迟,2.2小时)。在中风的第一年,大型TTP-LV组的筛子率为小于培养基TTP-LV组的两倍(35.7%,而不是17.4%; P <.001)。大型TTP-LV独立提出了筛子的危害(危险比,2.24; 95%置信区间,1.45-3.44)。本研究表明,通过在紧急情况下通过简单的几何方法测量的PWI上的TTP-LV可用于预测主要脑动脉症状闭塞患者的缺血性卒中的进展或复发。

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