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首页> 外文期刊>American Journal of Dermatopathology >Bleeding Papule on the Scapula: Answer
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Bleeding Papule on the Scapula: Answer

机译：肩cap骨上的出血性皮疹：答案

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In 1999, Carlson et al 1 described a new type of matrical neoplasm composed of matrical cells and dendritic melanocytes. They named it melanocytic matricoma. This tumor reproduced a normal anatomic phase that can be observed in the hair follicle bulb during anagen.1–6 In this regard, some authors have investigated the expression of cadherins and catenins 5–7 (proteins involved in hair follicle morphogenesis and formation of tumors related to it) in cases of melanocytic matricoma, finding that the distribution of these proteins is identical to that observed in the hair follicle anagen phase.From its description, there has been controversy about whether melanocytic matricoma could be considered a separate entity or just a variety of pigmented matricoma.8–12 Its typical clinical presentation is that of a pigmented papule less than 1 cm in diameter, well defined on sun-damaged skin, in patients older than 60 years. Including the present case, there have been, to our knowledge, 14 cases reported in humans (Table 1) and 1 in a dog.Histologically, the tumor appears as a well-demarcated dermal tumor forming solid nests and lobules composed of basaloid cells with matrical and supramatrical differentiation. There are dendritic melanocytes interspersed with these cells, and focally, shadow cells are present. The presence of atypia and mitotic figures in epithelial cells is common. Recently, a case of melanocytic matricoma has been described with similar findings in the melanocytic component.Clinical differential diagnosis must be made with pigmented basal cell carcinoma, malignant melanoma, and thrombosed hemangioma. Histological differential diagnosis is broader and should be performed with trichoblastoma and basal cell carcinoma with matrical differentiation, matricoma, pigmented pilomatricoma, proliferating pilomatricoma, and matrical carcinoma.1
机译：1999年，Carlson等[1]描述了一种由基质细胞和树突状黑色素细胞组成的新型基质肿瘤。他们将其命名为黑素细胞性基质瘤。该肿瘤重现了正常的解剖期，在生长期期间可在毛囊球中观察到。1–6在这方面，一些作者研究了钙粘蛋白和连环蛋白5–7（参与毛囊形态发生和肿瘤形成的蛋白质）的表达。在黑色素细胞性基质瘤的病例中，发现这些蛋白质的分布与毛囊毛发生长相中观察到的蛋白质分布相同。从其描述来看，关于黑色素细胞性基质瘤是否可被视为单独的实体还是仅是一个实体存在争议。各种色素沉着性基质瘤8-12。60岁以上患者的典型临床表现是直径小于1 cm的色素性丘疹，在受阳光伤害的皮肤上有很好的定义。包括本病例在内，据我们所知，已有14例人类（表1）和1只狗报告。从组织学上看，肿瘤表现为界限分明的真皮肿瘤，形成由巢状基底细胞组成的实心巢和小叶。母体和视网膜上的分化。有树突状黑素细胞散布在这些细胞中，并且集中存在影子细胞。上皮细胞中存在非典型性和有丝分裂现象是很常见的。近来，一例黑色素细胞性基质瘤的病例在黑色素细胞成分中也有类似发现。必须对色素性基底细胞癌，恶性黑色素瘤和血栓性血管瘤进行临床鉴别诊断。组织学鉴别诊断范围更广，应针对具有母体分化，基质细胞瘤，色素性皮瘤，增生性皮瘤和基质细胞瘤的母细胞母细胞瘤和基底细胞癌进行检查1。

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