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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Correlation of Changes in Leukocytes Levels 24 Hours after Intravenous Thrombolysis With Prognosis in Patients With Acute Ischemic Stroke
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Correlation of Changes in Leukocytes Levels 24 Hours after Intravenous Thrombolysis With Prognosis in Patients With Acute Ischemic Stroke

机译：急性缺血性卒中患者静脉溶栓后24小时白细胞水平的改变与急性缺血性卒中预后的相关性

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ObjectiveLeukocytes play a crucial role in inflammation and immune response. This study aims to demonstrate the value of changes in leukocytes levels 24 hours after intravenous thrombolysis to predict prognosis in acute ischemic stroke (AIS). MethodsFrom Jan 2016 to Oct 2017, the patients who suffered AIS to our center within 4.5 hours of symptom onset were all treated with recombinant tissue-type plasminogen activator. Data from 213 AIS patients were analyzed. Patients were divided into 4 groups: persistent leukocytosis (PL), transient leukocytosis (TL), leukocytosis 24 hours (L24H) and no leukocytosis (NL). By comparison, the factors with statistically significant were selected in pairwise multiple comparisons. Good clinical outcome was defined as the Modified Rankin Scale score of 2 or lower. Multivariate logistic regression was used to assess the association of the indicators with clinical outcome. ResultsBy pairwise multiple comparisons, PL and L24H had higher baseline National Institutes of Health Stroke Scale (NIHSS) score than NL and were likely to lead poor clinical outcomes. TL had a better prognosis than L24H. As the results of multivariable analyses shown, PL and L24H were risk factors to poor functional outcomes (odds ratio [OR] = 2.668, 95% confidence interval [CI] = 1.139-6.249,P= .024; OR?=?6.648, 95%CI?=?2.048-21.584,P= .002). ConclusionPersistent leukocytosis and leukocytosis 24 hours both had higher baseline NIHSS scores, more serious stroke and were more likely to lead to unfavorable outcome. Therefore, changes in leukocytes levels 24 hours after intravenous thrombolysis could be predicted the short-term functional outcome of AIS patients.
机译：客观型细胞在炎症和免疫应答中起着至关重要的作用。本研究旨在展示静脉内溶栓后24小时白细胞水平变化的价值，以预测急性缺血性卒中（AIS）的预后。方法从2016年1月至2017年10月，患有AIS在4.5小时内患者的症状发作后的患者均用重组组织型纤溶酶原激活剂治疗。分析了213例AIS患者的数据。患者分为4组：持续白细胞增多症（PL），瞬时白细胞增多（TL），白细胞增多24小时（L24H），无白细胞增多（NL）。相比之下，在成对多个比较中选择具有统计学意义的因素。良好的临床结果被定义为改进的Rankin Scale评分2或更低。多变量逻辑回归用于评估指标与临床结果的关联。结果由成对多次比较，PL和L24H具有更高的基线国家卫生冲程量表（NIHSS）得分，而不是NL，并且可能导致临床结果不佳。 T1具有比L24H更好的预后。作为所示的多变量分析结果，PL和L24H是缺乏功能结果的危险因素（差距[或] = 2.668,95％置信区间[CI] = 1.139-6.249，P = .024;或？6.648， 95％ci？=？2.048-21.584，p = .002）。结论24小时的白细胞增生和白细胞增多症两次均具有更高的基线NIHSS分数，更严重的中风，更有可能导致不利的结果。因此，可以预测AIS患者的短期功能结果，在静脉内溶栓后24小时的白细胞24小时变化。

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