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首页> 外文期刊>Journal of stroke and cerebrovascular diseases: The official journal of National Stroke Association >Helicopter “Drip and Ship” Flights Do Not Alter the Pharmacological Integrity of rtPA
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Helicopter “Drip and Ship” Flights Do Not Alter the Pharmacological Integrity of rtPA

机译：直升机“滴水和船”航班不会改变RTPA的药理完整性

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IntroductionRural and critical access hospitals rely on the “drip and ship” practice using helicopter emergency medical services (HEMS). But those helicopter flights are an unusual environment with physical factors such as vibration and accelerations that could potentially affect the stability, and pharmacological properties of IV rtPA, an issue that has not been previously addressed. Materials and MethodsThis was a prospective cohort study of consecutive acute ischemic stroke patients receiving IV rtPA through a Comprehensive Stroke Center from November 2015 to February 2017 to measure the effects of HEMS on the integrity and activity of rtPA by collecting residual medication left in the vial. Clinical Trial Registrationhttp://www.clinicaltrials.gov. NCT02752256 ResultsA total of 33 patients and rtPA samples were included; 18 patients who presented directly to the Comprehensive Stroke Center emergency department and 15 patients who received rtPA during air ambulance transfer. The median rtPA antigen concentration in the residual medication vial was 3.04 mg/mL (IQR: 1.24-3.87) in the HEMS group and 1.91 mg/mL (IQR: 1.33-2.60) in the controls (P= .168). There were no significant differences in rtPA activity or specific activity between the HEMS and control groups and there was no association between total HEMS flight time on overall rtPA specific activity. ConclusionsIn summary, this study provides supportive evidence of the lack of a detrimental effect of the HEMS physical environment on the integrity of rtPA, therefore endorsing current drip and ship practices without infusion adjustments.
机译：介绍和关键访问医院依靠使用直升机紧急医疗服务（HEMS）的“滴水和船舶”练习。但是那些直升机的航班是一个不寻常的环境，具有振动和加速等物理因素，可能会影响IV RTPA的稳定性，以及尚未解决的问题。材料和方法是通过从2015年11月到2017年11月至2017年2月通过综合中风中心接受IV RTPA的连续急性缺血性卒中患者的前瞻性队列研究，以衡量下摆对幼瓶中留下的残留药物的rtpa完整性和活性的影响。临床试验登记HTTP：//www.clinicaltrials.gov。 NCT02752256结果总共33名患者和RTPA样品; 18名患者直接向综合行程中心急诊部门和15名接受RTPA的患者展示。残留用药小瓶中的中位RTPA抗原浓度在下摆组中为3.04mg / ml（IQR：1.24-3.87），对照组1.91mg / ml（IQR：1.33-2.60）（P = .168）。 RTPA活性或下摆和对照组之间的特异性活动没有显着差异，并且在整体RTPA特异性活动中，HEL SHIFS飞行时间之间没有关联。结论综述，本研究提供了缺乏针对RTPA的完整性缺乏缺乏的有害影响的支持证据，因此在没有输液调整的情况下认可当前的滴水和船舶实践。

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